ArticleAmerican journal of translational research2022
Altered spontaneous neural activity in experimental odontogenic pain: a resting-state functional MRI study.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.
- Systematic review on effects of experimental orthodontic tooth displacement on brain activation assessed by fMRI.Clinical and experimental dental research · 2024Pooled it
- Cellular and Molecular Neuro-Bone Cell Interactions Drive Alveolar Bone Remodeling During Orthodontic Mechanical Loading.International journal of biological sciences · 2026Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to evaluate the intrinsic cerebral activity alternations in experimental odontogenic pain with resting-state functional magnetic resonance imaging (fMRI). MATERIALS AND
methodsForty-nine participants in an odontogenic pain group and 49 participants in control group underwent imaging using fMRI in this prospective study. Odontogenic pain was induced by experimental tooth movement. We calculated the fractional amplitude of low-frequency fluctuation (fALFF) value to evaluate regional cerebral function and compared it between the two groups utilizing a voxel-based two-sample t-test.
resultsIn comparison with the healthy controls, the participants in odontogenic pain group showed increased fALFF value in the left cerebellum, right posterior cingulate gyrus, and bilateral inferior temporal gyrus, as well as decreased fALFF in the medial prefrontal cortex, the left anterior cingulate cortex, bilateral angular gyrus, left inferior parietal cortex, middle temporal gyrus, and miscellaneous cerebral regions (P < 0.001 familywise error-corrected VOXEL > 100).
conclusionThe present study showed abnormal cerebral activity in odontogenic pain, and reveled that the aberrant regional functional activities were mainly located within the default mode network. The finding could provide insight into the underlying neural mechanism of odontogenic pain. Registry of clinical trials (Trial number ChiCTR1800018589) - http://www.chictr.org.cn/showproj.aspx?proj=31424.
Indexed as
Identifiers
36505321PMC9730070W4311288759What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.