ArticleAmerican journal of translational research2022
Correlation of serum miR-127 level with severity and prognosis of sepsis.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Biomimetic MOF Nanocarrier-Mediated Synergistic Delivery of Mitochondria and Anti-Inflammatory miRNA to Alleviate Acute Lung Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- MicroRNA Expression Profile in Patients Admitted to ICU as Novel and Reliable Approach for Diagnostic and Therapeutic Purposes.Molecular biotechnology · 2024Review
- Predictive Value of Combined Detection of Serum LGALS3BP and GDF-15 for the Prognosis of ICU Sepsis Patients.Infection and drug resistance · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the relationship of serum miR-127 level with the severity of sepsis patients and its predictive efficacy for prognosis.
methodsA total of 205 healthy individuals who underwent physical examination in Jingzhou Hospital Affiliated to Yangtze University and 205 patients with sepsis who were hospitalized in ICU from January 2021 to March 2022 were recruited in this study, and their serum miR-127 level were measured. The patients were divided into a high-miR-127 group (110 cases) and a low-miR-127 group (95 cases) based on the optimal cut-off value of miR-127 to assess the prognosis. The clinical data and 28-day survival of the two groups were analyzed. The patients were further divided into a death group (57 cases) and a survival group (148 cases) based on their 28-day survival. Factors associated with poor prognosis of sepsis were analyzed by Cox regression.
resultsThere were statistically significant differences in heart rate, body temperature, white blood cells (WBC), hemoglobin (Hb), procalcitonin (PCT), C-reactive protein (CRP), alanine aminotransferase (ALT), total bilirubin (TBIL), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), cardiac troponin I (cTnI), blood urea nitrogen (BUN), Prothrombin time (PT), serum creatinine (Scr), fibrinogen (FIB) and miR-127 between sepsis patients and healthy controls (
conclusionSerum miR-127 is highly expressed in sepsis and related to the severity of sepsis. Those with high miR-127 level have a higher risk of poor prognosis.
Indexed as
Identifiers
36505313PMC9730080W4311282689What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.