Evidence map›Paper›PMID 36505264›Full record

ArticleFrontiers in nutrition2022

Association between triglyceride-glucose index and worsening renal function in the elderly.

Li Lei, Hongbin Liang, Yali Qu, Qianhong Zhong, Qiuxia Zhang, Lei Dai, Junyan Lu, Min Xiao, Zhimeng Zhao, Fengyun Zhou and 4 more

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In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Li LeiDepartment of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Hongbin LiangDepartment of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yali QuDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
Qianhong ZhongDepartment of Respiratory Medicine, The Fourth People's Hospital of Foshan (Tuberculosis Control Center of Foshan), Foshan, China.
Qiuxia ZhangDepartment of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Lei DaiDepartment of Cardiology, Nanfang Hospital Zengcheng Branch, Guangzhou, China.
Junyan LuDepartment of Cardiology, Nanfang Hospital Zengcheng Branch, Guangzhou, China.
Min XiaoDepartment of Cardiology, Nanfang Hospital Zengcheng Branch, Guangzhou, China.
Zhimeng ZhaoDepartment of Respiratory Medicine, The Fourth People's Hospital of Foshan (Tuberculosis Control Center of Foshan), Foshan, China.
Fengyun ZhouDepartment of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yun LiDepartment of Public Health Management, Zengcheng Xintang Hospital, Guangzhou, China.
Guifang HuDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
Jiancheng XiuDepartment of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xinlu ZhangDepartment of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Triglyceride-glucose (TyG) index is a simple marker of insulin resistance. However, insufficient data is available on whether the TyG index is associated with worsening renal function (WRF) in the elderly. Therefore, this study was designed to explore the association between the TyG index and WRF based on a community elderly cohort. Methods: In this study, 7,822 elderly (aged ≥ 65 years) adults from southern China were enrolled and divided into four groups according to the TyG index quartiles. The primary endpoint was incident chronic kidney disease (CKD), defined as incident estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m Results: During the median 2.04 year follow-up period, 1,541 (19.7%) participants developed CKD. After adjusting for confounding factors, multivariable Cox regression models revealed significant associations between TyG index and incident CKD (HR per SD increase, 1.21; 95% CI: 1.14-1.29), a decline in eGFR of 30% (HR per SD increase, 1.38; 95% CI: 1.26-1.50), and decline in eGFR of 40% (HR per SD increase, 1.42; 95% CI: 1.24-1.63). Furthermore, compared with those in Q1, participants in Q4 demonstrated a higher risk of developing CKD (HR, 1.59; 95% CI: 1.35-1.88). These positive associations remained consistent across different subgroup populations. Conclusion: Our study suggests a positive and independent association between the TyG index and WRF in the elderly.

Indexed as

cohort studyelderlyinsulin resistancetriglyceride-glucose indexworsening renal function

Identifiers

PMID36505264
PMCPMC9730025

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