ArticleFrontiers in nutrition2022
Causal effects of B vitamins and homocysteine on obesity and musculoskeletal diseases: A Mendelian randomization study.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Using Mendelian randomization analyses in osteoarthritis: state of art and future perspectives.Annals of medicine · 2025Pooled it
- Editorial: Investigating the roles of nutritional determinants, genetic predispositions, and environmental risk factors in the development of obesity and associated metabolic disorders.Frontiers in nutrition · 2026Article
- Investigating the role of homocysteine and B vitamins in gestational diabetes mellitus: Mendelian randomization study.Nutrition journal · 2025Article
- Role of vitamins in the development and treatment of osteoporosis (Review).International journal of molecular medicine · 2025Review
- The causal role of homocysteine in multiple diseases: a systematic review of Mendelian randomization studies.Nutrition & metabolism · 2025Review
- Insights Into Causal Effects of Genetically Proxied Lipids and Lipid-Modifying Drug Targets on Cardiometabolic Diseases.Journal of the American Heart Association · 2025Article
- Association between dietary folate intake and the risk of osteoporosis in adults: a cross-sectional study.BMC musculoskeletal disorders · 2024Article
- Omeprazole and risk of osteoarthritis: insights from a mendelian randomization study in the UK Biobank.Journal of translational medicine · 2024Article
- Associations of Homocysteine, Folate, and Vitamin B12 with Osteoarthritis: A Mendelian Randomization Study.Nutrients · 2023Article
- Lifestyle habits and gastric cancer in an East Asian population: a Mendelian randomization study.Frontiers in oncology · 2023Article
- Bi-directional causal effect between vitamin B12 and non-alcoholic fatty liver disease: Inferring from large population data.Frontiers in nutrition · 2023Article
- Inferring causal effects of homocysteine and B-vitamin concentrations on bone mineral density and fractures: Mendelian randomization analyses.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Objectives: Although homocysteine (Hcy) increases the risk of cardiovascular diseases, its effects on obesity and musculoskeletal diseases remain unclear. We performed a Mendelian randomization study to estimate the associations between Hcy and B vitamin concentrations and their effects on obesity and musculoskeletal-relevant diseases in the general population. Methods: We selected independent single nucleotide polymorphisms of Hcy ( Results: Higher Hcy concentrations were robustly associated with an increased risk of knee osteoarthritis [odds ratio (OR) 1.119; 95% confidence interval (CI) 1.032-1.214; Conclusions: There exist significant causal effects of vitamin B12 in the serum and Hcy in the blood on fat and musculoskeletal diseases, respectively. These findings may have an important insight into the pathogenesis of obesity and musculoskeletal diseases and other possible future therapies.
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Registered trials
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