ArticleCureus2022
The Effect of a Novel Silver-Citrate Root Canal Irrigation Solution (BioAkt), Ethylenediamine Tetraacetic Acid (EDTA), and Citric Acid on the Microhardness of Root Canal Dentin: A Comparative In Vitro Study.
Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 6 citations in OpenAlex.
- Effect of dentin conditioners on biomarker release and microhardness of radicular dentin: an in vitro study.BMC oral health · 2026Article
- Effects of three final irrigation solutions with chelation properties on the erosion and mineral content of root canal dentin.European oral research · 2026Article
- Evaluation of the Cleanliness and Sealer Penetration of the Root Canal System Following Final Irrigation Using Chelating Agents.European endodontic journal · 2025Article
- Comparative Evaluation of the Effect of EDTA, Chitosan, Etidronic Acid, and Silver Citrate on the Mineral Content of Root Canal Dentin Using Energy Dispersive X-ray Spectroscopy: An In-Vitro Study.European endodontic journal · 2025Article
- Effect of Different Irrigating Solutions on Root Canal Dentin Microhardness-A Systematic Review with Meta-Analysis.Journal of functional biomaterials · 2024Review
- Article
- One-Step Surface-Treatment Reagent (35% 3-O-Ethyl-l-ascorbic Acid Plus 50% Citric Acid Solution) Restores the Shear Bond Strength of Metal Brackets Bonded to Bleached Human Enamel: An In Vitro Study.Dentistry journal · 2023Article
- [Edta concentration in the effectiveness of antimicrobial photodynamic therapy with curcumin onRevista cientifica odontologica (Universidad Cientifica del Sur)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objective The use of a chelating agent as an adjunct to disinfectant irrigation is very necessary to remove the smear layer formed during root canal treatment. However, the decalcifying solutions have a negative impact on dentin microhardness, which might affect the result of endodontic therapy. The aim of this study is to evaluate the effect of 17% ethylenediamine tetraacetic acid (EDTA), a novel silver-citrate root canal irrigation solution (BioAkt), 10% citric acid, and 40% citric acid on the microhardness of root canal dentin. Materials and methods Forty-five single-root teeth were distributed equally into five groups A, B, C, D, and E treated with distilled water as a control, 17% EDTA, BioAkt, 10% citric acid, and 40% citric acid, respectively. The dentin microhardness was measured before and after the experiment, and the collected data were analyzed using paired sample T-test, One-way ANOVA test, and least significant difference (LSD) test (multiple comparisons), (P < 0.05). Result The results showed that the averages of dentin microhardness values before the experiment were 62.83 kg/mm², 65.34 kg/mm², 64.79 kg/mm², 62.95 kg/mm², and 56.47 kg/mm² for groups A, B, C, D, and E, respectively, while the averages after the experiment were 62.60 kg/mm², 54.92 kg/mm², 54.50 kg/mm², 51.31 kg/mm², and 49.37kg/mm² accordingly. Statistical analysis revealed that 17% EDTA, BioAkt, 10% citric acid, and 40% citric acid decreased the dentin microhardness significantly comparing with the negative control group, without statistical differences among them. Conclusion The chelating agents 17% EDTA, BioAkt, 10% citric acid, and 40% citric acid declined the microhardness of root canal dentin similarly, which might have possible effects on endodontic treatment and the properties of root canal filling materials as well.
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