Evidence map›Paper›PMID 36505088›Full record

ReviewFrontiers in physiology2022

Signaling pathways in cutaneous wound healing.

Olga Krizanova, Adela Penesova, Jozef Sokol, Alica Hokynkova, Amir Samadian, Petr Babula

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 53 citations in OpenAlex.

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  14. Regeneration of the skin wound by two different crosslinkers:Iranian journal of basic medical sciences · 2025
    Article
  15. Current drug discovery technologies · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Olga KrizanovaInstitute of Clinical and Translational Research, Biomedical Research Center SAS, Bratislava, Slovakia.
Adela PenesovaInstitute of Clinical and Translational Research, Biomedical Research Center SAS, Bratislava, Slovakia.
Jozef SokolDepartment of Chemistry, Faculty of Natural Sciences, University of St. Cyril and Methodius, Trnava, Slovakia.
Alica HokynkovaDepartment of Burns and Plastic Surgery, Faculty of Medicine, Masaryk University and University Hospital, Brno, Czechia.
Amir SamadianDepartment of Physiology, Faculty of Medicine, Masaryk University, Brno, Czechia.
Petr BabulaDepartment of Physiology, Faculty of Medicine, Masaryk University, Brno, Czechia.
Masaryk University · CZUniversity of Ss. Cyril and Methodius in Trnava · SKBiomedical Research Center of the Slovak Academy of Sciences · SKUniversity Hospital Brno · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing is a very complex process, where variety of different pathways is activated, depending on the phase of healing. Improper or interrupted healing might result in development of chronic wounds. Therefore, novel approaches based on detailed knowledge of signalling pathways that are activated during acute or chronic cutaneous wound healing enables quicker and more effective healing. This review outlined new possibilities of cutaneous wound healing by modulation of some signalling molecules, e.g., gasotransmitters, or calcium. Special focus is given to gasotransmitters, since these bioactive signalling molecules that can freely diffuse into the cell and exert antioxidative effects. Calcium is an important booster of immune system and it can significantly contribute to healing process. Special interest is given to chronic wounds caused by diabetes mellitus and overcoming problems with the inflammation.

Indexed as

calciumdiabetes mellitusgasotransmittershydrogen peroxidewound healing

Identifiers

PMID36505088
PMCPMC9732733
OpenAlexW4310040238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.