Evidence map›Paper›PMID 36505046›Full record

ArticleFrontiers in physiology2022

Adenosine reduces sinoatrial node cell action potential firing rate by uncoupling its membrane and calcium clocks.

Ashley N Wirth, Kenta Tsutsui, Victor A Maltsev, Edward G Lakatta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ashley N WirthLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Biomedical Research Center, Baltimore, MD, United States.
Kenta TsutsuiLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Biomedical Research Center, Baltimore, MD, United States.
Victor A MaltsevLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Biomedical Research Center, Baltimore, MD, United States.
Edward G LakattaLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Biomedical Research Center, Baltimore, MD, United States.
Institute on Aging · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The spontaneous action potential (AP) firing rate of sinoatrial nodal cells (SANC) is regulated by a system of intracellular Ca

Indexed as

adenosinecalcium releasecardiac arrhythmiacoupled-clock pacemaker systemsarcoplasmic reticulum (SR)sick sinus syndromesinoatrial node (SAN)sinus node arrest

Identifiers

PMID36505046
PMCPMC9730041
OpenAlexW4309848924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.