ArticleFrontiers in public health2022
Trends in global burden of diseases attributable to lead exposure in 204 countries and territories from 1990 to 2019.
Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Relationship between lead exposure and different types of hypertension: systematic review and dose-response meta-analysis.Frontiers in public health · 2025Pooled it
- WHO estimates of the global, regional, and national burden of 42 foodborne infectious and chemical hazards, 2000-21: an updated data synthesis.The Lancet. Global health · 2026Review
- Diosgenin-loaded niosomes ameliorate cadmium-induced neurotoxicity and endocrine disruption in female rats through modulation of oxidative stress, apoptosis, and inflammatory markers.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Interpretable Machine Learning in Heavy Metal-Associated Cardiovascular and Metabolic Disease: A Review of Current Methodologies, Toxicological Insights, and Clinical Implications.Cardiovascular toxicology · 2026Review
- Potential Antidote Against Lead Toxicity-A Review.International journal of molecular sciences · 2026Review
- Blood lead levels in children and soil lead contamination in a former mining area in Germany.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Global Burden of Lead Exposure: Integrating Epidemiology, Molecular Mechanisms, and Mitigation Approaches.Health science reports · 2026Article
- The Burdens of Idiopathic Developmental Intellectual Disability Attributable to Lead Exposure from 1990 to 2023 and a Projection to 2050 in the USA: Findings from the Global Burden of Disease Study 2023.Healthcare (Basel, Switzerland) · 2026Article
- Association of metal and metalloid exposure with cardiovascular-kidney-metabolic syndrome: mediation by inflammation, oxidative stress, and aging.BMC public health · 2025Article
- Polydatin Mitigates Lead-Induced Nephropathy by Modulating Oxidative Stress, Inflammation, and the AMPK/AKT/Nrf2 Pathway in Rats.Biological trace element research · 2025Article
- The burden and trend prediction of ischemic heart disease associated with lead exposure: Insights from the Global Burden of Disease study 2021.Environmental health : a global access science source · 2025Article
- Burdens of idiopathic developmental intellectual disability attributable to lead exposure from 1990 to 2021 and projection to 2035 in China: findings from the 2021 global burden of disease study.Frontiers in public health · 2025Article
- Global burden of mental disorders among adolescents and young adults, 1990-2021: a systematic analysis of the Global Burden of Diseases Study 2021.General psychiatry · 2025Article
- Spatiotemporal patterns of rheumatic heart disease burden attributable to high systolic blood pressure, high sodium diet, and lead exposure (1990 to 2019): a longitudinal observational study.Frontiers in nutrition · 2024Article
- Salt use patterns and heavy metal urinary excretion.Frontiers in nutrition · 2024Article
- Trends in urine lead and associated mortality in US adults: NHANES 1999-2018.Frontiers in nutrition · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lead hazards are ubiquitous in the environment, and lead exposure has been proved to damage human health. Nevertheless, there is limited data on the global burden of diseases attributable to lead exposure. In this study, we evaluated the temporal-spatial trend of disease burden caused by lead exposure in 204 countries and territories from 1990 to 2019. Methods: Based on Global Burden of Disease (GBD) Study 2019, deaths, disability-adjusted life years (DALYs), age-standardized mortality rate (ASMR) and DALYs rate (ASDR) were estimated by region, country, sex and age. The estimated annual percentage change (EAPC) was calculated to assess the temporal trends of ASMR and ASDR between 1990 and 2019. Results: Global deaths increased from 0.53 (95% UI: 0.31, 0.77) to 0.90 (95% UI: 0.55, 1.29) million, and the number of DALYs increased from 16.02 (95% UI: 10.32, 22.17) to 21.68 (95% UI: 13.81, 30.30) million between 1990 and 2019. China, India and Bangladesh were top three countries with the largest number of deaths and DALYs in 2019. The ASMR (per 100,000 population) decreased from 14.47 (95% UI: 8.40, 21.43) to 11.48 (95% UI: 7.00, 16.49) with EAPC of -0.75 (95% UI: -0.87, -0.64), and the ASDR (per 100,000 population) decreased from 378.01 (95% UI: 240.55, 524.18) to 267.52 (95% UI: 170.57, 373.44) with EAPC of -1.19 (95% UI: -1.32, -1.07). Most of disease burden of lead exposure occurred in the men and elderly population. Stroke and ischemic heart disease were two key sources of disease burden of lead exposure. Also, a negative association between sociodemographic index (SDI) and disease burden of lead exposure was observed. Conclusions: Lead exposure poses a significant disease burden globally, and is still a great threat to public health. Primary prevention measures of reducing lead exposure in the environment are essential.
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