Evidence map›Paper›PMID 36504960›Full record

ArticleFrontiers in public health2022

Analysis of the gut microbiome in obese native Tibetan children living at different altitudes: A case-control study.

Wenqi Du, Linxun Liu, Yan Ma, Qinfang Zhu, Ruhan Jia, Ying Han, Ziyi Wu, Xin Yan, Ainiwaer Ailizire, Wei Zhang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Wenqi DuResearch Center for High Altitude Medicine, Qinghai University School of Medicine, Xining, China.
Linxun LiuGeneral Surgery Department, Qinghai Provincial People's Hospital, Xining, China.
Yan MaResearch Center for High Altitude Medicine, Qinghai University School of Medicine, Xining, China.
Qinfang ZhuResearch Center for High Altitude Medicine, Qinghai University School of Medicine, Xining, China.
Ruhan JiaResearch Center for High Altitude Medicine, Qinghai University School of Medicine, Xining, China.
Ying HanResearch Center for High Altitude Medicine, Qinghai University School of Medicine, Xining, China.
Ziyi WuDepartment of Public Health, Qinghai University School of Medicine, Xining, China.
Xin YanDepartment of Public Health, Qinghai University School of Medicine, Xining, China.
Ainiwaer AilizireDepartment of Public Health, Qinghai University School of Medicine, Xining, China.
Wei ZhangResearch Center for High Altitude Medicine, Qinghai University School of Medicine, Xining, China.
Qinghai University · CNQinghai Provincial Peoples Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To explore the relationship between intestinal flora and obesity in Tibetan children at different altitudes. Methods: Using16S rRNA gene sequencing results and blood lipid metabolism indexes to study the characteristics of the intestinal flora present in faeces and changes in blood lipid metabolism in obese children in Tibet who reside at different altitudes and to study correlations between blood lipid metabolism indicators and the intestinal flora composition. Results: The results showed the following. (a) The triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) levels in the obesity groups were higher than those in the normal-weight groups, and those in the high-altitude obesity groups were lower than those in the low-altitude obesity groups. (b) The 16S rRNA gene sequencing results showed that altitude affected the composition and relative abundance of the gut microbiota. These parameters were basically the same among the low-altitude groups, while they were significantly lower in the high-altitude groups than in the low-altitude groups. (c) Groups that lived at different altitudes and had different body weights had different dominant bacterial genera. Conclusions: The intestinal flora diversity varied by body weight and altitude, with lower diversity in those at higher altitudes and with lower body weights.

Indexed as

Gastrointestinal MicrobiomePediatric ObesityBody WeightCase-Control StudiesChildCholesterol, LDLHumansRNA, Ribosomal, 16STriglyceridesCholesterol, LDLRNA, Ribosomal, 16STriglyceridesgut microbiomehigh altitudemetabolismobesityschoolchildren

Identifiers

PMID36504960
PMCPMC9731119
OpenAlexW4309914801

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.