Evidence map›Paper›PMID 36504809›Full record

ArticleFrontiers in microbiology2022

Young MSM changed temporal HIV-1 epidemic pattern in Heilongjiang Province, China.

Qing-Hai Li, Jia-Ye Wang, Si-Yu Liu, Yun-Qi Zhang, En-Long Li, Yi-Ru Wang, Shu-Lei Zhang, Wen-Bo Zhao, Shu-Lin Liu, Xiao-Hong Chen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Qing-Hai LiGenomics Research Center, College of Pharmacy, Harbin Medical University, Harbin, China.
Jia-Ye WangDepartment of Microbiology, Harbin Medical University, Harbin, China.
Si-Yu LiuDepartment of Infectious Diseases, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Yun-Qi ZhangDepartment of Microbiology, Harbin Medical University, Harbin, China.
En-Long LiDepartment of Microbiology, Harbin Medical University, Harbin, China.
Yi-Ru WangDepartment of Microbiology, Harbin Medical University, Harbin, China.
Shu-Lei ZhangGenomics Research Center, College of Pharmacy, Harbin Medical University, Harbin, China.
Wen-Bo ZhaoGenomics Research Center, College of Pharmacy, Harbin Medical University, Harbin, China.
Shu-Lin LiuGenomics Research Center, College of Pharmacy, Harbin Medical University, Harbin, China.
Xiao-Hong ChenDepartment of Infectious Diseases, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Fu-Xiang WangDepartment of Infectious Diseases, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Human immunodeficiency virus type 1 (HIV-1) epidemic in China is featured by geographical diversity of epidemic patterns. Understanding the characteristics of regional HIV-1 epidemic allows carrying out targeted prevention and controlling measures. This seven-year cross-sectional study was conducted in Heilongjiang, one province of Northeast China, where newly diagnosed infection is fast increasing yearly, but temporal HIV-1 epidemic trend is largely unknown. Methods: Information of 1,006 newly diagnosed HIV-1-infected participants were collected before antiretroviral therapy during 2010-2016 in Heilongjiang province. HIV-1 genotype was identified based on the viral Results: Homosexual contact among men who have sex with men (MSM) was the main transmission route and CRF01_AE was the most dominant HIV-1 genotype. During 2010-2016, the HIV-1 epidemic showed three new changes: the median age continued to decline, the cases with a CD4 count more than 500 cells/μl (CD4hi cases) disproportionally expanded, and the recent HIV-1 infection rate steadily increased. MSM cases determined the temporal trend of HIV-1 epidemic here. Increase of young MSM cases (aged <30 years) made the main contribution to the younger age trend of MSM cases. These young MSM exhibited a higher median CD4 count, a higher proportion of CD4hi cases, and a higher rate of recent HIV-1 infection than cases aged 30 years and more. MSM infected by CRF01_AE virus mostly affected HIV-1 epidemic patterns among MSM population. Conclusion: Young MSM have become a new hotspot and vulnerable group for HIV-1 transmission in Heilongjiang Province, Northeast China. The rapid increase in the number of young MSM cases, mainly those with CRF01_AE infection, changed temporal HIV-1 epidemic pattern here. Measures for prevention and control of HIV-1 infection among this population are urgently needed in the future.

Indexed as

CRF01_AEHIV-1 epidemicimmune statusrecent infectionyoung men who have sex with men

Identifiers

PMID36504809
PMCPMC9732660
OpenAlexW4310036615

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.