ArticleFrontiers in human neuroscience2022
The effect of home-based transcranial direct current stimulation in cognitive performance in fibromyalgia: A randomized, double-blind sham-controlled trial.
Article in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03843203 (Efficacy and Effectivity of Long Term Home Based tDCS in Fibromyalgia), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Effectivity of Long Term Home Based tDCS in Fibromyalgia: an Explanatory Randomized Clinical Trial
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Clinical, neurophysiological and neurochemical effects of non-invasive electrical brain stimulation in fibromyalgia syndrome-a systematic review and meta-analysis.Frontiers in pain research (Lausanne, Switzerland) · 2025Pooled it
- Trial
- Strength Training Versus Walking on the Fibromyalgia Impact: A Blinded Randomised Controlled Trial.Musculoskeletal care · 2025Trial
- Cortical excitability and analgesic effects of multisite transcranial direct current stimulation targeting the motor cortex and cerebellum in fibromyalgia.Scientific reports · 2025Trial
- Home-Based Transcranial Direct Current Stimulation vs Placebo for Fibromyalgia: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Trial
- Effects of Transcranial Direct Current Stimulation Versus Sham Stimulation on Brain-Derived Neurotrophic Factor and Clinical Outcomes: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Non-Invasive Brain Stimulation for Core Symptoms of Chronic Primary Pain: A Meta-Analysis of RCTs.Brain sciences · 2026Review
- Effectiveness of Physiotherapy Interventions on Executive Function in Patients with Chronic Pain: A Systematic Review.Neurology international · 2026Review
- Home use of low-intensity transcranial electrical stimulation in clinical practice: an IFCN handbook chapter.Clinical neurophysiology practice · 2026Review
- Determinants of adherence and safety in fully autonomous home-based transcranial direct current stimulation for fibromyalgia.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Fibromyalgia: A Review of the Pathophysiological Mechanisms and Multidisciplinary Treatment Strategies.Biomedicines · 2024Review
- The effect of transcranial alternating current stimulation on cognitive flexibility and attention of children with intellectual disability: a case report.Journal of medical case reports · 2024Article
- Non-Invasive Electric and Magnetic Brain Stimulation for the Treatment of Fibromyalgia.Biomedicines · 2023Review
- Would frontal midline theta indicate cognitive changes induced by non-invasive brain stimulation? A mini review.Frontiers in human neuroscience · 2023Review
- Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Transcranial Direct Current Stimulation (tDCS) is a promising approach to improving fibromyalgia (FM) symptoms, including cognitive impairment. So, we evaluated the efficacy and safety of home-based tDCS in treating cognitive impairment. Besides, we explored if the severity of dysfunction of the Descendant Pain Modulation System (DPMS) predicts the tDCS effect and if its effect is linked to changes in neuroplasticity as measured by the brain-derived neurotrophic factor (BDNF). Methods: This randomized, double-blind, parallel, sham-controlled clinical trial, single-center, included 36 women with FM, aged from 30 to 65 years old, assigned 2:1 to receive a-tDCS ( Results: GLM showed a main effect for treatment in the TMT-B-A [Wald χ2 = 6.176; Df = 1; Conclusion: These findings revealed that daily treatment with a home-based tDCS device over l-DLPFC compared to sham stimulation over 4 weeks improved the cognitive impairment in FM. The a-tDCS at home was well-tolerated, underlining its potential as an alternative treatment for cognitive dysfunction. Besides, the a-tDCS effect is related to the severity of DPMS dysfunction and changes in neuroplasticity state. Clinical trial registration: [www.ClinicalTrials.gov], identifier [NCT03843203].
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.