Evidence map›Paper›PMID 36504619›Full record

ArticleGerms2022

A comparative study of the clonal diversity and virulence characteristics of uropathogenic

Dylan John Astley, Labolina Spang, Fatemeh Parnian, Tara Vollmerhausen, Huseyin Kilic, Mehmet Hora, Aycan Gundogdu, Mohammad Katouli

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Germs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Dylan John AstleyBSc, School of Science, Technology and Engineering, University of the Sunshine Coast, Maroochydore DC 4558, Queensland, Australia.
Labolina SpangBSc, School of Science, Technology and Engineering; University of the Sunshine Coast, Maroochydore DC 4558, Queensland, Australia.
Fatemeh ParnianBSc, School of Science, Technology and Engineering, University of the Sunshine Coast, Maroochydore DC 4558, Queensland, Australia.
Tara VollmerhausenPhD, School of Science, Technology and Engineering, University of the Sunshine Coast, Maroochydore DC 4558, Queensland, Australia.
Huseyin KilicPhD, Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Erciyes University, Kayseri 38039, Turkey.
Mehmet HoraPhD, Genome and Stem Cell Center (GenKok), Erciyes University, Kayseri, Turkey.
Aycan GundogduPhD, Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Erciyes University, Turkey and Genome and Stem Cell Center (GenKok), Erciyes University, Kayseri 38039, Turkey.
Mohammad KatouliPhD, School of Science, Technology and Engineering and Centre for Bioinnovation, University of the Sunshine Coast, Maroochydore DC 4558, Queensland, Australia.
University of the Sunshine Coast · AUErciyes University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The virulence-associated gene (VAG) repertoire and clonal organization of uropathogenic Methods: A total of 715 UPEC strains isolated from Australian (n=361) and Turkish (n=354) children and adults with hospital (HA)- and community-acquired (CA)-UTIs were included in this study. Typing of the strains using RAPD-PCR and PhPlate fingerprinting grouped all strains into 25 clonal groups (CGs). CG representatives were phylogrouped and screened for the presence of 18 VAGs associated with extraintestinal pathogenic Results: Turkish UPEC strains were characterized by high clonal diversity and predominance of the phylogroup D, while few distinct clonal groups with phylogenetic group B2 backgrounds dominated among the Australian strains. Twelve identical CGs were shared between ≥1 patient group from either country. Australian strains, particularly those isolated from children with HA-UTI, showed higher virulence potential than their Turkish counterparts, carrying significantly more genes associated with adhesion, iron acquisition and capsule biosynthesis. Conclusions: This study identified identical CGs of UPEC causing HA- and CA-UTIs among Australian and Turkish UTI patients. These CGs frequently carried VAGs associated with adhesion, iron acquisition, immune evasion, and toxin production, which may contribute to their ability to disseminate internationally and to cause UTI.

Indexed as

AustraliaTurkeyurinary tract infectionUropathogenic Escherichia coli

Identifiers

PMID36504619
PMCPMC9719378
OpenAlexW4292528442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.