Evidence map›Paper›PMID 36504337›Full record

ArticleWorld journal of urology2023

Maternal family history of urolithiasis is associated with earlier age of onset of stone disease.

Rei Unno, Kazumi Taguchi, Gregory Hosier, Manint Usawachintachit, Wilson Sui, Heiko Yang, Fadl Hamouche, David Bayne, Marshall Stoller, Thomas Chi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. The effects of elevated phosphate on the kidney - damaging the gatekeeper.Pflugers Archiv : European journal of physiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Rei UnnoDepartment of Urology, University of California, San Francisco, USA.
Kazumi Taguchi *Department of Urology, University of California, San Francisco, USA.
Gregory HosierDepartment of Urology, University of California, San Francisco, USA.
Manint UsawachintachitDepartment of Urology, University of California, San Francisco, USA.
Wilson SuiDepartment of Urology, University of California, San Francisco, USA.
Heiko YangDepartment of Urology, University of California, San Francisco, USA.
Fadl HamoucheDepartment of Urology, University of California, San Francisco, USA.
David BayneDepartment of Urology, University of California, San Francisco, USA.
Marshall StollerDepartment of Urology, University of California, San Francisco, USA.
Thomas ChiDepartment of Urology, University of California, San Francisco, 400 Parnassus Ave., Sixth Floor, Suite A610, San Francisco, CA, 94143, USA. tom.chi@ucsf.edu.
University of California, San Francisco · USThai Red Cross Society · TH

Funding

UCSF-Kaiser Urological Epidemiology Research Career Development ProgramK12DK111028 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ALISON · 2016 to 2025
$5.3M
NIDDK NIH HHS K12 DK111028
6 · The paper itself

Abstract

purposeTo evaluate the impact of detailed family history on the severity of disease and age of onset in patients with urolithiasis.

methodsProspectively collected data from a single institution between October 2015 and December 2020 were analyzed. Our primary endpoint was the number of patients experiencing at least one recurrent stone during the follow-up period.

resultsOf 1566 patients analyzed, 603 (39%) reported at least one family member with a history of stones. The percentage of patients experiencing at least one recurrent stone event was higher in patients with a family history of stones (38%) compared to those without a family history of stones (28%) over a median follow-up period of 8 months (p = 0.001). On multivariate analysis, the presence of any family history of urolithiasis increased risk of recurrent stone events (odds ratio [OR] 1.62, p < 0.001). The presence of both a first- and a second-degree relative with urolithiasis was associated with higher odds for a recurrent stone event (OR 2.17; p = 0.003) and a younger age of onset for stones, (OR 3.32; < 0.001). A maternal-side relative with stones conferred a higher odds ratio for younger age of first onset of stones (OR 2.93; p < 0.001).

conclusionAny family history of kidney stone disease imparts an increased risk of recurrent stone event and an earlier age of onset for urolithiasis. The presence of both first- and second-degree relatives or a maternal-side relative with kidney stones may be a predictor for an earlier age of onset for urolithiasis.

Indexed as

Kidney CalculiUrolithiasisAge of OnsetFamilyHumansMultivariate AnalysisRetrospective StudiesDegree of relativeFamily historyMaternal-side relativePaternal-side relativeRecurrent stone events

Identifiers

PMID36504337
PMCPMC10044450
OpenAlexW4311074410

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.