Evidence map›Paper›PMID 36504327›Full record

ArticleObesity (Silver Spring, Md.)2023

Reduced muscle strength (dynapenia) in women with obesity confers a greater risk of falls and fractures in the UK Biobank.

Lisa Dowling, Daniel J Cuthbertson, Jennifer S Walsh

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07180485 (The Effectiveness of Whole Body Vibration Training in Improving Brain Activity, Bone Mineral Density, Quality of Life, and Biomarkers for the Older People With Dynapenic Abdominal Obesity), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07180485 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Effectiveness of Whole Body Vibration Training in Improving Brain Activity, Bone Mineral Density, Quality of Life, and Biomarkers for the Older People With Dynapenic Abdominal Obesity

TypeinterventionalSponsorDalin Tzu Chi General HospitalRan2025 to 2027Enrolled120ConditionsDynapenia, Abdominal ObesityArmswhole body vibration training, control group
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  4. Association between obesity and the prevalence of fractures: a population-based cross-sectional study in China.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Lisa DowlingOncology and Metabolism, Medical School, The University of Sheffield, Sheffield, UK.ORCID 0000-0002-8332-358X
Daniel J CuthbertsonDepartment of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, The University of Liverpool, Liverpool, UK.ORCID 0000-0002-6128-0822
Jennifer S WalshOncology and Metabolism, Medical School, The University of Sheffield, Sheffield, UK.
University of Sheffield · GBUniversity of Liverpool · GB

Funding

Medical Research Council MC_PC_17228Medical Research Council MR/P020941/1
6 · The paper itself

Abstract

objectiveThis study aimed to determine the independent effects of obesity and dynapenia on falls risk, areal bone mineral density, and fracture risk (lower extremity or all other fractures).

methodsA total of 16,147 women (aged 60-82 years) from the UK Biobank were categorized by handgrip strength (HGS; dynapenia status: HGS ≤ 21 kg) and body weight (BMI: normal weight, overweight, or obesity). Multiple logistic regression models examined the association among dynapenia and obesity and self-reported falls (previous 12 months), lower extremity fractures, and all other fractures (previous 5 years).

resultsA total of 3793/16,147 women fell, and 1413/15,570 (9.1%) eligible women experienced fall-related fractures. Obesity (odds ratio [OR] 1.25; 95% CI: 1.12-1.38) and dynapenia (OR 0.87; 95% CI: 0.77-0.98) were both independently associated with greater lower extremity fracture risk, independently of areal bone mineral density. However, considering all other fracture sites, obesity conferred protection (OR 0.77; 95% CI: 0.61-0.96), except in those with low HGS, who had an equivalent fracture risk to those with normal weight (OR 1.06; 95% CI: 0.82-1.38).

conclusionsDynapenia further increases the increased risk of leg and ankle fractures in obesity and counteracts the protective effects of obesity on fracture risk at all other sites (wrist, arm, hip, spine, other bones).

Indexed as

Accidental FallsFractures, BoneBiological Specimen BanksBone DensityFemaleHand StrengthHumansObesityRisk FactorsUnited Kingdom

Identifiers

PMID36504327
PMCPMC10108064
OpenAlexW4311204178

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.