ArticleSurgery today2023
Prophylactic negative pressure wound therapy following colorectal perforation: defining the risk factors for delayed wound healing.
Article in Surgery today, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- [Risk factors for overall postoperative complications in elderly patients undergoing gastrointestinal surgeries: a multicenter observational study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Observational
- Delayed Primary Skin Closure Followed by Single-use Negative-pressure Wound Therapy Is Optimal for Wound Management After Bowel-stoma Reversal.In vivo (Athens, Greece)Observational
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe World Health Organization recommends prophylactic negative pressure wound therapy (NPWT) for high-risk SSI wounds, despite which delayed wound healing (DWH) remains a problem. The aim of this study was to define the risk factors for DWH under prophylactic NPWT following colorectal perforation (CP).
methodsThe subjects of this retrospective study were patients who underwent emergency laparotomy and prophylactic NPWT for CP between 2011 and 2019 at Fujisawa City Hospital in Japan. Multivariable analysis was performed to identify which perioperative factors impact DWH.
resultsA total of 58 patients met the inclusion criteria and the median period from surgery to wound closure was 12 days (IQR: 8-18). Most factors, including preoperative steroid use, diabetes, and serum albumin, were not associated with DWH, although patients requiring catecholamine were more likely to have DWH (OR 7.81, 95% CI 1.55-39.24, p = 0.013). The median in-hospital cost was more than double for patients with DWH vs. those without DWH (41.36 kUSD [IQR 24.95-51.89] vs. 20.32 kUSD [IQR 16.69-28.45], p < 0.001).
conclusionCatecholamine use was a greater risk factor for DWH than previously reported factors such as diabetes and the serum albumin level. Further study is needed to investigate strategies to prevent DWH and optimize the utilization of NPWT, especially in patients requiring catecholamine.
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