Evidence map›Paper›PMID 36504064›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[Astragalus polysaccharide protects against blood-brain barrier damage in MCAO rats by inhibiting P2X7R channel].

Q Yuan, L Xie, C Chen

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Targeting P2X Receptors-Current Progress in Sepsis.International journal of inflammation · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Q YuanGuangzhou University of Chinese Medicine, Guangzhou 510800, China.
L XieDepartment of Encephalopathy, Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou 510800, China.
C ChenDepartment of Encephalopathy, Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou 510800, China.
Integrated Chinese Medicine (China) · CNGuangzhou University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the protective effect of astragalus polysaccharide (APS) against blood-brain barrier in a rat model of middle cerebral artery occlusion (MCAO) and the role of P2X7R channel in the protective mechanism.

methodsIn rat microglial cell models of oxygen and glucose deprivation (OGD) or ATP treatment, the formation of blood-brain barrier

resultsIn the

conclusionAPS can protect the brain tissue of MCAO rats by stabilizing the internal environment, down-regulating the expression of MMP-9 and improving the permeability of blood-brain barrier under cerebral ischemia and hypoxia, and its mechanism may involve the inhibition of P2X7R channel.

Indexed as

Blood-Brain BarrierInfarction, Middle Cerebral ArteryAdenosine TriphosphateAnimalsEvans BlueGlucoseMatrix Metalloproteinase 9OxygenPolysaccharidesRatsRats, Sprague-DawleyAdenosine TriphosphateEvans BlueGlucoseMatrix Metalloproteinase 9OxygenPolysaccharidesastragalus polysaccharidesblood-brain barriermatrix metalloproteinase-9P2X7R channel

Identifiers

PMID36504064
PMCPMC9742771
OpenAlexW4311663891

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.