ArticleMicrobiome2022
The global distribution and environmental drivers of the soil antibiotic resistome.
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Article in Microbiome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55citing papers in PubMed
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55 citing papers in PubMed, 122 citations in OpenAlex.
- From Rhizosphere to Resistance: Microbe-Plant Interactions in Eco-Smart Biocontrol.MicrobiologyOpen · 2026Review
- Soil Acidification Enriches Antibiotic Resistome.Global change biology · 2026Article
- Evolution, Mechanisms, and Therapeutic Implications of Mobile Tetracycline Destructases.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Dominant Role of Habitat Transformation in Driving the Divergence of Health-Risk Related Microbial Functional Genes in Karst Mountain Parks: A Metagenomic Study.Ecology and evolution · 2026Article
- Predicting the absence of World Health Organization fungal priority pathogens in agricultural soils using machine learning and ITS metabarcoding.Die Naturwissenschaften · 2026Article
- Environmental effectiveness of the National Action Plan to Contain Antimicrobial Resistance: evidence from Chinese soil.National science review · 2026Article
- Multidrug-resistant Enterobacterales in commercial laying and free-range hens (Gallus gallus domesticus) under semiarid conditions of the Caatinga biome.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Article
- Soil Resistomes in a Tropical Watershed are Indirectly Structured by Bacterial Community Interactions with Soil Properties.bioRxiv : the preprint server for biology · 2026Article
- Article
- Animal husbandry and environmental conditions are associated with cefotaxime-resistantmedRxiv : the preprint server for health sciences · 2026Article
- Assessing the Ecological Roles of Resistomes within Microbial Communities in Antibiotic-contaminated Ecosystems.Microbial ecology · 2026Review
- Soil microbial and plant responses to increasing antibiotic concentration: a case study of five antibiotics.Applied and environmental microbiology · 2026Article
- Metagenomic Profiling of Soil Microbiomes and Resistomes in Arid Ecosystems of Kuwait.Antibiotics (Basel, Switzerland) · 2026Article
- Soil antibiotic resistome in farmland exhibits higher diversity and horizontal transfer potential than adjacent pastureland in agro-pastoral ecotone.Environmental microbiome · 2026Article
- Comparative genomic insights into the genus Pantoea: genetic determinants of ecological lifestyle diversity and plant growth-promoting potential.World journal of microbiology & biotechnology · 2026Article
- Macroecological processes impact Australian soil resistomes and climatically stable regions with anthropogenic activities serve as ARG hotspots.The ISME journal · 2026Article
- Oral dysbiosis: methodological evolution, the mobile resistome and the future of machine learning in dentistry.Journal of oral microbiology · 2026Review
- A comparison of antibiotic resistance reports in pharmacovigilance databases and conventional surveillance across "One Health".Frontiers in public health · 2026Article
- Animal husbandry and environmental conditions are associated with cefotaxime-resistant Escherichia coli in yard soil in peri-urban Malawi.PLOS global public health · 2026Article
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Authors and funding
39 authors at 20 institutions in 17 countries.
Manuel Delgado-BaquerizoLaboratorio de Biodiversidad y Funcionamiento Ecosistémico. Instituto de Recursos Naturales y Agrobiología de Sevilla (IRNAS), CSIC, Av. Reina Mercedes 10, E-41012, Sevilla, Spain. M.delgado.baquerizo@csic.es.
Hang-Wei Hu *Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia. hang-wei.hu@unimelb.edu.au.
Fernando T MaestreInstituto Multidisciplinar para el Estudio del Medio "Ramón Margalef", Universidad de Alicante, Carretera de San Vicente del Raspeig s/n, 03690 San Vicente del Raspeig, Alicante, Spain.
Carlos A GuerraGerman Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Puschstrasse 4, 04103, Leipzig, Germany.
Nico EisenhauerGerman Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Puschstrasse 4, 04103, Leipzig, Germany.
David J EldridgeCentre for Ecosystem Science, School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, New South Wales, 2052, Australia.
Yong-Guan ZhuState Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Qing-Lin ChenFaculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
Pankaj TrivediMicrobiome Network and Department of Agricultural Biology, Colorado State University, Fort Collins, CO, 80523, USA.
Shuai DuState Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Thulani P MakhalanyaneDepartment of Biochemistry, Genetics and Microbiology, Centre for Microbial Ecology and Genomics, University of Pretoria, Pretoria, 0028, South Africa.
Jay Prakash VermaPlant-Microbe Interactions Lab., Institute of Environment and Sustainable Development, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
Beatriz GozaloInstituto Multidisciplinar para el Estudio del Medio "Ramón Margalef", Universidad de Alicante, Carretera de San Vicente del Raspeig s/n, 03690 San Vicente del Raspeig, Alicante, Spain.
Victoria OchoaInstituto Multidisciplinar para el Estudio del Medio "Ramón Margalef", Universidad de Alicante, Carretera de San Vicente del Raspeig s/n, 03690 San Vicente del Raspeig, Alicante, Spain.
Sergio AsensioInstituto Multidisciplinar para el Estudio del Medio "Ramón Margalef", Universidad de Alicante, Carretera de San Vicente del Raspeig s/n, 03690 San Vicente del Raspeig, Alicante, Spain.
Ling WangInstitute of Grassland Science/School of Life Science, Northeast Normal University, and Key Laboratory of Vegetation Ecology, Ministry of Education, Changchun, 130024, Jilin, China.
Eli ZaadyAgricultural Research Organization, Department of Natural Resources, Institute of Plant Sciences, Gilat Research Center, Mobile Post, 8531100, Negev, Israel.
Javier G IllánDepartment of Entomology, Washington State University, Pullman, WA, 99164, USA.
Christina SiebeInstituto de Geología, Universidad Nacional Autónoma de México, Ciudad Universitaria, México City D.F., CP, 04510, México.
Tine GrebencDepartment of Forest Physiology and Genetics, Slovenian Forestry Institute, Ljubljana, Slovenia.
Xiaobing ZhouState Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, CAS, Urumqi, China.
Yu-Rong LiuCollege of Resources and Environment, Huazhong Agricultural University, Wuhan, 430070, China.
Adebola R BamigboyeNatural History Museum, Obafemi Awolowo University, Ile-Ife, Nigeria.
José L Blanco-PastorINRAE, UR4 (URP3F), Centre Nouvelle-Aquitaine-Poitiers, Lusignan, France.
Jorge DuranMisión Biolóxica de Galicia, Consejo Superior de Investigaciones Científicas, 36143, Pontevedra, Spain.
Alexandra RodríguezDepartment of Life Sciences, Centre for Functional Ecology, University of Coimbra, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal.
Steven MametCollege of Agriculture and Bioresources Department of Soil Science, University of Saskatchewan, Saskatoon, SK, S7N 5A8, Canada.
Fernando AlfaroGEMA Center for Genomics, Ecology & Environment, Universidad Mayor, Santiago, Chile.
Sebastian AbadesGEMA Center for Genomics, Ecology & Environment, Universidad Mayor, Santiago, Chile.
Alberto L TeixidoDepartamento de Botânica e Ecologia, Instituto de Biociências, Universidade Federal de Mato Grosso, Av. Fernando Corrêa, 2367, Boa Esperança, Cuiabá, MT, 78060-900, Brazil.
Gabriel F Peñaloza-BojacáLaboratório de Sistemática Vegetal, Departamento de Botânica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil.
Marco A Molina-MontenegroCentro de Ecología Integrativa, ICB, Universidad de Talca, Talca, Chile.
Cristian Torres-DíazGrupo de Biodiversidad y Cambio Global (BCG), Departamento de Ciencias Básicas, Universidad del Bío-Bío, Campus Fernando May, Chillán, Chile.
Cecilia PerezInstituto de Ecología y Biodiversidad, Las Palmeras 3425, Santiago, Chile.
Antonio GallardoUnidad Asociada CSIC-UPO (BioFun), Universidad Pablo de Olavide, 41013, Sevilla, Spain.
Laura García-VelázquezDepartamento de Sistemas Físicos, Químicos y Naturales, Universidad Pablo de Olavide, 41013, Sevilla, Spain.
Patrick E HayesSchool of Biological Sciences, The University of Western Australia, Perth, WA, 6009, Australia.
Sigrid NeuhauserInstitute of Microbiology, University of Innsbruck, Innsbruck, Austria.
Ji-Zheng He *Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia. jizheng.he@unimelb.edu.au.
University of Alicante · ESUniversidad Mayor · CLUniversidad Pablo de Olavide · ESUniversity of Melbourne · AUAgricultural Research Organization · ILBanaras Hindu University · INChinese Academy of Sciences · CNColorado State University · USFujian Normal University · CNHuazhong Agricultural University · CNInstitute of Ecology and Biodiversity · CLInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · FRInstituto de Recursos Naturales y Agrobiología de Sevilla · ESLeipzig University · DEMartin Luther University Halle-Wittenberg · DEMisión Biológica de Galicia · ESNortheast Normal University · CNObafemi Awolowo University · NGResearch Center for Eco-Environmental Sciences · CNSlovenian Forestry Institute · SI
Funding
Australian Research Council DP210100332Austrian Science Fund FWF Y 801British Ecological Society MUSGONET LRA17\1193Horizon 2020 CLIMIFUN
Abstract
backgroundLittle is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth's largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs.
resultsWe show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs.
conclusionsTogether, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome. Video Abstract.
Indexed as
Anti-Bacterial AgentsSoilEcologyHumansPhenotypeAnti-Bacterial AgentsSoilAntibiotic resistanceGlobal changeGlobal scaleHuman healthMobile genetic elements
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