ArticleMicrobiome2022
Multidrug-resistant Acinetobacter pittii is adapting to and exhibiting potential succession aboard the International Space Station.
Article in Microbiome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- High-qualityMicrobiology spectrum · 2026Article
- Review
- Genomic characterization of Microbacterium meiriae sp. nov., a novel bacterium isolated from the International Space Station.Scientific reports · 2025Article
- Genomic Characterization of a Carbapenem-ResistantPathogens (Basel, Switzerland) · 2025Article
- Touching Surfaces - Presence of microorganisms on antimicrobial metal surfaces on the International Space Station and in German schools.BMC microbiology · 2025Article
- Article
- The evolution of superbugs in space: a genomic perspective on pathogens in the International Space Station environment.Journal, genetic engineering & biotechnology · 2025Article
- An early microbial landscape: inspiring endeavor from the China Space Station Habitation Area Microbiome Program (CHAMP).Science China. Life sciences · 2025Article
- Article
- Systematic screening of 42 vancomycin-resistant Enterococcus faecium strains for resistance, biofilm, and desiccation in simulated microgravity.NPJ microgravity · 2024Article
- Article
- The human microbiome in space: parallels between Earth-based dysbiosis, implications for long-duration spaceflight, and possible mitigation strategies.Clinical microbiology reviews · 2024Review
- An interstrand DNA crosslink glycosylase aidsProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight.Nature microbiology · 2024Article
- Microbial adaptation to spaceflight is correlated with bacteriophage-encoded functions.Nature communications · 2024Article
- Evolution of homologous recombination rates across bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Phylogenomics, phenotypic, and functional traits of five novel (Earth-derived) bacterial species isolated from the International Space Station and their prevalence in metagenomes.Scientific reports · 2023Article
- Viral activation and ecological restructuring characterize a microbiome axis of spaceflight-associated immune activation.Research square · 2023Article
- Phylogenetic affiliations and genomic characterization of novel bacterial species and their abundance in the International Space Station.Research square · 2023Article
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7 authors.
Funding
Abstract
backgroundMonitoring the adaptation of microorganisms to the extreme environment of the International Space Station (ISS) is crucial to understanding microbial evolution and infection prevention. Acinetobacter pittii is an opportunistic nosocomial pathogen, primarily impacting immunocompromised patients, that was recently isolated from two missions aboard the ISS.
resultsHere, we report how ISS-associated A. pittii (n = 20 genomes) has formed its own genetically and functionally discrete clade distinct from most Earth-bound isolates (n = 291 genomes). The antimicrobial susceptibility testing of ISS strains and two related clinical isolates demonstrated that ISS strains acquired more resistance, specifically with regard to expanded-spectrum cephalosporins, despite no prediction of increased resistance based on genomic analysis of resistance genes. By investigating 402 longitudinal environmental and host-associated ISS metagenomes, we observed that viable A. pittii is increasing in relative abundance and therefore potentially exhibiting succession, being identified in >2X more metagenomic samples in back-to-back missions. ISS strains additionally contain functions that enable them to survive in harsh environments, including the transcriptional regulator LexA. Via a genome-wide association study, we identified a high level of mutational burden in methionine sulfoxide reductase genes relative to the most closely related Earth strains.
conclusionsOverall, these results indicated a step forward in understanding how microorganisms might evolve and alter their antibiotic resistance phenotype in extreme, resource-limited, human-built environments. Video Abstract.
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