ArticleBMC plant biology2022
Transcriptome analysis provides insights into light condition effect on paclitaxel biosynthesis in yew saplings.
Article in BMC plant biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 29 citations in OpenAlex.
- Genome-Wide Analysis ofCurrent issues in molecular biology · 2026Article
- Recent advances inFrontiers in plant science · 2026Review
- Article
- Screening ofSynthetic and systems biotechnology · 2024Article
- Transcriptome and metabolome analysis reveals mechanism of light intensity modulating iridoid biosynthesis in Gentiana macrophylla Pall.BMC plant biology · 2024Article
- Phylogeny and expression patterns of ERF genes that are potential reproductive inducers in hybrid larch.BMC genomics · 2024Article
- Regulatory microRNAs and phasiRNAs of paclitaxel biosynthesis inFrontiers in plant science · 2024Article
- Trends in the Tissue Culture Techniques and the Synthesis of Bioactive Compounds inPlants (Basel, Switzerland) · 2023Review
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTaxus is a rare gymnosperm plant that is the sole producer of the anticancer drug paclitaxel. The growth and development of Taxus is affected by environmental factors such as light. However, little is known about how light conditions affect growth and metabolic processes, especially paclitaxel biosynthesis.
resultsIn this study, we applied three different light conditions to Taxus chinensis young saplings and investigated the physiological response and gene expression. Our observations showed that exposure to high light led to oxidative stress, caused photoinhibition, and damaged the photosynthetic systems in T. chinensis. The paclitaxel content in T. chinensis leaves was significantly decreased after the light intensity increased. Transcriptomic analysis revealed that numerous genes involved in paclitaxel biosynthesis and phenylpropanoid metabolic pathways were downregulated under high light. We also analyzed the expression of JA signaling genes, bHLH, MYB, AP2/ERF transcription factors, and the CYP450 families that are potentially related to paclitaxel biosynthesis. We found that several CYP450s, MYB and AP2/ERF genes were induced by high light. These genes may play an important role in tolerance to excessive light or heat stress in T. chinensis.
conclusionsOur study elucidates the molecular mechanism of the effects of light conditions on the growth and development of T. chinensis and paclitaxel biosynthesis, thus facilitating the artificial regeneration of Taxus and enhancing paclitaxel production.
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