Evidence map›Paper›PMID 36503371›Full record

SynthesisInternational journal of stroke : official journal of the International Stroke Society2023

Stroke in Africa: A systematic review and meta-analysis of the incidence and case-fatality rates.

Akinkunmi Paul Okekunle, Stephanie Jones, Olaleye Adeniji, Caroline Watkins, Maree Hackett, Gian Luca Di Tanna, Mayowa Owolabi, Rufus Akinyemi

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of stroke : official journal of the International Stroke Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Delays in the Stroke Care Pathway in a Low-Income Setting: An Audit Study from Mozambique.International journal of environmental research and public health · 2025
    Observational
  11. Revisiting Africa's Stroke Obstacles and Services (SOS).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Stroke characteristics and outcomes in urban Tanzania: Data from the Prospective Lake Zone Stroke Registry.International journal of stroke : official journal of the International Stroke Society · 2024
    Article
  18. Non-cigarette Tobacco Use and Stroke Among West Africans: Evidence From the SIREN Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024
    Article
  19. Review
  20. Empowering sickle cell disease care: the rise ofFrontiers in rehabilitation sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Akinkunmi Paul OkekunleDepartment of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.ORCID 0000-0003-4825-4934
Stephanie JonesUniversity of Central Lancashire, Preston, UK.ORCID 0000-0001-9149-8606
Olaleye AdenijiNeurology Unit, Department of Medicine, Federal Medical Centre, Abeokuta, Nigeria.
Caroline WatkinsUniversity of Central Lancashire, Preston, UK.ORCID 0000-0002-9403-3772
Maree HackettUniversity of Central Lancashire, Preston, UK.ORCID 0000-0003-1211-9087
Gian Luca Di TannaThe George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.
Mayowa OwolabiDepartment of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.ORCID 0000-0003-1146-3070
Rufus AkinyemiDepartment of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.ORCID 0000-0001-5286-428X

Funding

H3Africa Administrative Coordinating Centre: Enabling and Supporting Genomics and Health Research Capacity Building in AfricaU24HG009780 · NHGRI · UNIVERSITY OF CAPE TOWN · PI SKELTON, MICHELLE · 2017 to 2022
$4.8M
Stroke Investigative Research & Educational Network (SIREN)U54HG007479 · NHGRI · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI OVBIAGELE, BRUCE, OWOLABI, MAYOWA OJO · 2013 to 2017
$4.2M
CNV And Stroke (CaNVAS)R01NS114045 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI COLE, JOHN W. · 2020 to 2024
$2.6M
African Rigorous Innovative Stroke Epidemiological Surveillance (ARISES)R01NS115944 · NINDS · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI OVBIAGELE, BRUCE, OWOLABI, MAYOWA OJO · 2020 to 2025
$2.2M
Systematic Investigation of Blacks with Stroke - Genomics (SIBS-Genomics) StudyR01NS107900 · NINDS · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI OVBIAGELE, BRUCE, OWOLABI, MAYOWA OJO · 2018 to 2021
$1.8M
Training Africans to Lead and Execute Neurological Trials & Studies (TALENTS)D43TW012030 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OVBIAGELE, BRUCE · 2021 to 2025
$1.2M
African Neurobiobank for Precision Stroke Medicine - (ELSI) ProjectU01HG010273 · NHGRI · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI AKINYEMI, RUFUS OLUSOLA, ARULOGUN, OYEDUNNI SOLA · 2018 to 2022
$512k
Sub-Saharan Africa Conference on Stroke (SSACS) ConferenceR13NS115395 · NINDS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI OVBIAGELE, BRUCE · 2020 to 2020
$50k
FIC NIH HHS D43 TW012030NHGRI NIH HHS U01 HG010273NHGRI NIH HHS U24 HG009780NHGRI NIH HHS U54 HG007479NINDS NIH HHS R01 NS107900NINDS NIH HHS R01 NS114045NINDS NIH HHS R01 NS115944NINDS NIH HHS R13 NS115395
6 · The paper itself

Abstract

backgroundThe burden of stroke (a leading cause of disability and mortality) in Africa appears to be increasing, but a systematic review of the best available data to support or refute this observation is lacking.

aimTo determine the incidence and 1-month case-fatality rates from high-quality studies of stroke epidemiology among Africans. SUMMARY OF REVIEW: We searched and retrieved eligible articles on stroke epidemiology among indigenous Africans in bibliographic databases (MEDLINE, ScienceDirect, Google Scholar, and Cochrane library) using predefined search terms from the earliest records through January 2022. Methodological assessment of eligible studies was conducted using the Newcastle-Ottawa scale. Pooling of incidence and case-fatality rates was performed via generalized linear models (Poisson-Normal random-effects model). Of the 922 articles retrieved, 14 studies were eligible for inclusion. The total number of stroke cases was 2568, with a population denominator (total sample size included in population-based registries or those who agreed to participate in door-to-door community studies) of 3,384,102. The pooled crude incidence rate of stroke per 100,000 persons in Africa was 106.49 (95% confidence interval (CI) = 58.59-193.55),

conclusionThe burden of stroke in Africa remains very high. However, little is known about the dynamics of stroke epidemiology among Africans due to the dearth of high-quality evidence. Further continent-wide rigorous epidemiological studies and surveillance programs using the World Health Organization STEPwise approach to Surveillance (WHO STEPS) framework are needed.

Indexed as

StrokeAfricaFemaleHumansIncidenceMaleWorld Health OrganizationAfricacase fatalityepidemiologyincidencemeta-analysisStrokesystematic review

Identifiers

PMID36503371
PMCPMC10313746

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.