Evidence map›Paper›PMID 36503344›Full record

ArticleAnnals of medicine2023

High endothelial venules proportion in tertiary lymphoid structure is a prognostic marker and correlated with anti-tumor immune microenvironment in colorectal cancer.

Zhao Zhan, Liu Shi-Jin, Zhang Yi-Ran, Liu Zhi-Long, Zhao Xiao-Xu, Ding Hui, Yun-Long Pan, Jing-Hua Pan

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Article in Annals of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Zhao ZhanDepartment of General Surgery, the First Affiliated Hospital of Jinan University, Guangzhou, China.
Liu Shi-JinDepartment of General Surgery, the First Affiliated Hospital of Jinan University, Guangzhou, China.
Zhang Yi-RanDepartment of General Surgery, the First Affiliated Hospital of Jinan University, Guangzhou, China.
Liu Zhi-LongDepartment of Hepatobiliary Surgery, the First Affiliated Hospital of Jinan University, Guangzhou, China.
Zhao Xiao-XuDepartment of General Surgery, the First Affiliated Hospital of Jinan University, Guangzhou, China.
Ding HuiDepartment of General Surgery, the First Affiliated Hospital of Jinan University, Guangzhou, China.
Yun-Long PanDepartment of General Surgery, the First Affiliated Hospital of Jinan University, Guangzhou, China.
Jing-Hua PanDepartment of General Surgery, the First Affiliated Hospital of Jinan University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh endothelial venules (HEV) and tertiary lymphoid structures (TLS) are associated with clinical outcomes of patients with colorectal cancer (CRC). However, because HEV are components of TLS, there have been few studies of the role of the HEV proportion in TLS (HEV/TLS). This study investigated the role of the HEV/TLS and its relationship with the tumor immune microenvironment in CRC.

methodsA retrospective analysis of 203 cases of tissue pathologically diagnosed as CRC after general surgery was performed at the First Affiliated Hospital of Jinan University from January 2014 to July 2017. Paraffin sections were obtained from the paracancerous intestinal mucosal tissues. The area of HEV and TLS and immune cells were detected by immunohistochemistry. We further divided the positive HEV expression group into the high HEV/TLS group and the low HEV/TLS group by the average area of HEV/TLS. After grouping, the data were also analyzed using the chi-square test, Kaplan-Meier method, and univariate and multivariate Cox proportional risk regression analyses. A correlation analysis of the HEV/TLS and immune cells as well as angiogenesis was performed.

resultsPatients with a high HEV/TLS in CRC tissue were associated with longer OS, DFS and lower TNM stage. Meanwhile, CRC tissue with a high HEV/TLS showed a greater ability to recruit the CD3+ T cells, CD8+ T cells and M1 macrophages and correlated with less angiogenesis. Conclusively, high HEV/TLS links to the favorable prognosis of CRC patients and correlated with anti-tumor immune microenvironment, which can be a potential biomarker for prognosis of CRC patients.

conclusionA high HEV/TLS is associated with a favorable prognosis for CRC and is correlated with the anti-tumor immune microenvironment. Therefore, it is a potential biomarker of the CRC prognosis.KEY MESSAGESHigh HEV/TLS is associated with a favorable prognosis for CRC.High HEV/TLS correlated with the anti-tumor immune microenvironment of CRC and can serve as a novel prognostic biomarker.

Indexed as

Colorectal NeoplasmsTertiary Lymphoid StructuresBiomarkersHumansPrognosisRetrospective StudiesTumor MicroenvironmentBiomarkersclinicopathologic characteristicsdisease-free survivalhigh endothelial venules (HEV)overall survivalTertiary lymphoid structure (TLS)tumor

Identifiers

PMID36503344
PMCPMC9754014

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.