ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Diagnostic and Prognostic Significance of the Prothrombin Time/International Normalized Ratio in Sepsis and Septic Shock.
Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Prognostic value of international normalized ratio in cancer patients with sepsis: A retrospective cohort study and secondary analysis.Medicine · 2026Article
- Development and validation of a predictive model for septic shock in maternal sepsis: a retrospective cohort study in a single referral center.BMC pregnancy and childbirth · 2026Article
- Clinical Performance of BIO-S and BIO-SC Composite Bioscores for 28-Day Mortality Stratification in Adults with Sepsis and Septic Shock.Biomedicines · 2026Article
- Establishment and validation of a machine learning-based prediction model for sepsis-induced coagulopathy.Journal of thrombosis and thrombolysis · 2026Article
- Prognostic Value of International Normalized Ratio and Thrombocytopenia in Early Risk Stratification of Septic Patients.Biomedicines · 2026Article
- Possible contribution of the STAT3 signaling pathway to disseminated intravascular coagulation (DIC) in mice with cecal ligation and puncture-induced sepsis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Association between Lok index and all-cause mortality among sepsis patients in critical care: insights from the MIMIC-IV database.BMC infectious diseases · 2026Article
- A Novel Composite Bioscore Integrating Biomarkers, Clinical Scores, and Comorbidity Indices for Prognostic Stratification in Sepsis.Journal of inflammation research · 2026Article
- Association between activated partial thromboplastin time and septic shock in pregnant women: a retrospective cohort study.Frontiers in medicine · 2026Article
- Temporal phenotyping and prognostic stratification of patients with sepsis through longitudinal clustering.BioData mining · 2025Article
- Article
- Parenclitic network mapping predicts survival in critically ill patients with sepsis.Physiological reports · 2025Article
- Interpretable machine learning for predicting optimal surgical timing in polytrauma patients with TBI and fractures to reduce postoperative infection risk.Scientific reports · 2025Article
- Development and Validation of a Nomogram for Predicting Sepsis-Induced Coagulopathy in Septic Patients: Mixed Retrospective and Prospective Cohort Study.Thrombosis and haemostasis · 2025Article
- Early prediction of sepsis-induced coagulopathy in the ICU using interpretable machine learning: a multi-center retrospective cohort study.Frontiers in medicine · 2025Article
- Under the background of the new global definition of ARDS: an interpretable machine learning approach for predicting 28-day ICU mortality in patients with sepsis complicated by ARDS.Frontiers in physiology · 2025Article
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- Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe study investigates the diagnostic and prognostic significance of the prothrombin time/international normalized ratio (PT/INR) in patients with sepsis and septic shock.
backgroundSepsis may be complicated by disseminated intravascular coagulation (DIC). While the status of coagulopathy of septic patients is represented within the sepsis-3 definition by assessing the platelet count, less data regarding the prognostic impact of the PT/INR in patients admitted with sepsis and septic shock is available.
methodsConsecutive patients with sepsis and septic shock from 2019 to 2021 were included. Blood samples were retrieved from day of disease onset (ie, day 0), as well as on day 1, 2, 4, 6 and 9 thereafter. Firstly, the diagnostic value of the PT/INR in comparison to the activated partial thromboplastin time (aPTT) was tested for septic shock compared to sepsis without shock. Secondly, the prognostic value of the PT/INR for 30-day all-cause mortality was tested. Statistical analyses included univariable t-tests, Spearman's correlations, C-statistics, Kaplan-Meier analyses and Cox proportional regression analyses.
results338 patients were included (56% sepsis without shock, 44% septic shock). The overall rate of all-cause mortality at 30 days was 52%. With an area under the curve (AUC) of 0.682 (
conclusionThe PT/INR revealed moderate diagnostic accuracy for septic shock but was associated with reliable prognostic accuracy with regard to 30-day all-cause mortality in patients admitted with sepsis and septic shock.
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