Evidence map›Paper›PMID 36503241›Full record

ReviewAmerican journal of physiology. Cell physiology2023

Integration of quantitative methods and mathematical approaches for the modeling of cancer cell proliferation dynamics.

Michael Cotner, Sarah Meng, Tyler Jost, Andrea Gardner, Carolina De Santiago, Amy Brock

Abstract readReview
In one paragraph

Review in American journal of physiology. Cell physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Multistage carcinogenesis in occupational cholangiocarcinoma: the impact of clonal expansion and risk estimation.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2024
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael CotnerDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas.ORCID 0000-0002-9274-5346
Sarah MengDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas.ORCID 0000-0003-3530-412X
Tyler JostDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas.
Andrea GardnerDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas.
Carolina De SantiagoDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas.
Amy BrockDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas.ORCID 0000-0001-8255-9024

Funding

Comprehensive Training Program in Imaging Science and InformaticsT32EB007507 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI MARKEY, MIA K, RYLANDER, HENRY GRADY · 2009 to 2024
$2.7M
The Allee Effect in Tumor InitiationR01CA226258 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI BROCK, AMY, HUANG, SUI · 2018 to 2022
$2.3M
Using label-free Raman microscopy to predict therapeutic resistance of TNBC cellsU01CA253540 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI BROCK, AMY, YANKEELOV, THOMAS E · 2020 to 2024
$2.1M
NCI NIH HHS R01 CA226258NCI NIH HHS U01 CA253540NIBIB NIH HHS T32 EB007507
6 · The paper itself

Abstract

Physiological processes rely on the control of cell proliferation, and the dysregulation of these processes underlies various pathological conditions, including cancer. Mathematical modeling can provide new insights into the complex regulation of cell proliferation dynamics. In this review, we first examine quantitative experimental approaches for measuring cell proliferation dynamics in vitro and compare the various types of data that can be obtained in these settings. We then explore the toolbox of common mathematical modeling frameworks that can describe cell behavior, dynamics, and interactions of proliferation. We discuss how these wet-laboratory studies may be integrated with different mathematical modeling approaches to aid the interpretation of the results and to enable the prediction of cell behaviors, specifically in the context of cancer.

Indexed as

Models, BiologicalNeoplasmsCell ProliferationHumansModels, Theoreticalgrowth dynamicsmathematical modelingproliferationquantitative biology

Identifiers

PMID36503241
PMCPMC9886359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.