Evidence map›Paper›PMID 36503240›Full record

ArticleAmerican journal of physiology. Cell physiology2023

Ecto-5'-nucleotidase (Nt5e/CD73)-mediated adenosine signaling attenuates TGFβ-2 induced elastin and cellular contraction.

Rolando A Cuevas, Ryan Wong, Pouya Joolharzadeh, William J Moorhead, Claire C Chu, Jack Callahan, Alex Crane, Camille K Boufford, Angelina M Parise, Aneesha Parwal and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Rolando A CuevasDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0002-3571-5845
Ryan WongDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0002-1251-758X
Pouya JoolharzadehDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
William J MoorheadDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Claire C ChuDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0002-1735-5137
Jack CallahanDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Alex CraneDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Camille K BouffordDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0003-1019-9431
Angelina M PariseDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Aneesha ParwalDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Parya BehzadiDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Cynthia St HilaireDivision of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0003-1871-6915
University of Pittsburgh · US

Funding

Regulation of Vascular Calcification by Adenosine SignalingK22HL117917 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ST. HILAIRE, CYNTHIA · 2015 to 2017
$731k
American Heart Association-American Stroke Association 902641NHLBI NIH HHS K22 HL117917
6 · The paper itself

Abstract

Arterial calcification due to deficiency of CD73 (ACDC) is a rare genetic disease caused by a loss-of-function mutation in the

Indexed as

5'-NucleotidaseAdenosineCalcinosisElastinJoint DiseasesSignal TransductionTransforming Growth Factor betaVascular Diseases5'-NucleotidaseAdenosineElastinTransforming Growth Factor betaA2b adenosine receptorelastinNT5E/CD73smooth muscle cellvascular remodeling

Identifiers

PMID36503240
PMCPMC9902218
OpenAlexW4311199959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.