ArticleAnnals of geriatric medicine and research2022
Trajectories, Transitions, and Trends in Frailty among Older Adults: A Review.
Article in Annals of geriatric medicine and research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Challenges in Identifying Biomarkers of Frailty Syndrome: A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Article
- Metabolic Syndrome as a Determinant of Bidirectional Transitions Between Frailty States: Evidence From the Whitehall II Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- QR Code-Enabled Self-Access Lifestyle Education in Older People Living With HIV: Pragmatic Pilot Quasi-Experimental Pretest-Posttest Implementation Study.Journal of medical Internet research · 2026Article
- Colon Capsule Endoscopy-Measured Colonic Transit Time Is Associated with Frailty in Older Adults.Medicina (Kaunas, Lithuania) · 2026Article
- Associations of sociodemographic and behavioral factors with frailty transition patterns: a multi-state Markov analysis of the China Health and Retirement Longitudinal Study (CHARLS).Archives of public health = Archives belges de sante publique · 2026Article
- Long-Term Functional Outcomes After Prehabilitation in Frail Older Adults Undergoing Colorectal Cancer Surgery: A One-Year Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Exploring educational needs on frailty outside geriatrics: a survey of European Union of Medical Specialists' bodies.European geriatric medicine · 2026Article
- L-shaped association of plasma creatinine with frailty in oldest‑old: Evidence from a cross-sectional study of CLHLS.Scientific reports · 2026Article
- Association of Frailty and Perioperative Outcomes Across Surgical Specialties Between 2016 and 2018 Using the National Inpatient Sample Database: A Retrospective Cohort Study.Health science reports · 2026Article
- Adverse Drug Reaction-Related Hospital Admissions and Adverse Drug Events and Their Association with Short- and Long-Term Health Outcomes in Older Adults.Geriatrics (Basel, Switzerland) · 2026Article
- Osteosarcopenia, bone-muscle interactions, and frailty risk: A prospective cohort study of community-dwelling older adults.Aging clinical and experimental research · 2025Article
- Chained mediation of interleukins linking fluoride exposure to frailty: a cohort study of skeletal fluorosis patients in China.Environmental health : a global access science source · 2025Article
- Gut frailty: the core of reversing frailty.Annals of medicine · 2025Article
- A survey on the trajectory of frailty in the middle-aged and elderly population in the Chengdu community: a retrospective observational study.BMC public health · 2025Observational
- Core principles and structures of geriatric rehabilitation: a narrative review.Ewha medical journal · 2025Article
- Whether a polyethylene terephthalate bottle cap can be opened could serve as a common indicator for locomotive syndrome, frailty and sarcopenia.Geriatrics & gerontology international · 2025Article
- Article
- Frailty in older adults admitted to hospital: a six-year dual-centre retrospective study of over 53 000 clinical frailty scale assessments.Age and ageing · 2025Observational
- Frailty in motion: Amnestic mild cognitive impairment and Alzheimer's disease cohorts display heterogeneity in multimorbidity classification and longitudinal transitions.Journal of Alzheimer's disease : JAD · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frailty is an age-related clinical state associated with deterioration across multiple physiological systems and a leading cause of morbidity and mortality later in life. To understand how frailty develops and what causes its progression, longitudinal data with repeated frailty measurements are required. This review summarizes evidence from longitudinal studies on frailty trajectories, transitions, and trends. We identified several consistent findings: frailty increases with aging and is a dynamic condition, and more recent generations of older adults have higher frailty levels. These findings have both clinical and public health relevance, including the provision of healthcare and aged care services in the coming years. Further studies are required, particularly those conducted in low- and middle-income countries and those investigating factors associated with changes in frailty. The latter may help develop better-targeted interventions to reverse or slow the progression of frailty.
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Registered trials
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