Evidence map›Paper›PMID 36503155›Full record

Trial reportJournal of pain and symptom management2023

Examining Caregiver Outcomes in the CONNECT Intervention for Patients With Advanced Cancer.

Wagahta Semere, Andrew D Althouse, Robert Arnold, Douglas White, Thomas J Smith, Edward Chu, Margaret Q Rosenzweig, Yael Schenker

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of pain and symptom management, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07516314 (ACT to Reduce Morbidity and Mortality in Hematopoietic Stem Cell Transplant), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07516314 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

ACT to Reduce Morbidity and Mortality in Hematopoietic Stem Cell Transplant (HCT) Patients (ACTivate)

TypeinterventionalSponsorAnthony Sung, MDRan2026 to 2031Enrolled476ConditionsStem Cell Transplant PatientsArmsACTivate sessions
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wagahta SemereDivision of General Internal Medicine at Zuckerberg San Francisco General Hospital, University of California, San Francisco (W.S.), San Francisco, California, USA. Electronic address: wagahta.semere@ucsf.edu.
Andrew D AlthouseUniversity of Pittsburgh School of Medicine (A.D.A., Y.S.), Pittsburgh, Pennsylvania, USA.
Robert ArnoldDivision of General Internal Medicine, Section of Palliative Care and Medical Ethics (R.A.), University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Douglas WhiteProgram on Ethics and Decision Making in Critical Illness, Department of Critical Care Medicine (D.W.), University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Thomas J SmithPalliative Medicine Program (T.J.S.), The Johns Hopkins Hospital, Baltimore, Maryland, USA.
Edward ChuAlbert Einstein Cancer Center (E.C.), New York, New York.
Margaret Q RosenzweigSchool of Nursing, University of Pittsburgh (M.Q.R.), Pittsburgh, Pennsylvania, USA.
Yael SchenkerUniversity of Pittsburgh School of Medicine (A.D.A., Y.S.), Pittsburgh, Pennsylvania, USA; Palliative Research Center (PaRC) (Y.S.), University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
A cluster randomized trial of a primary palliative care intervention (CONNECT) for patients with advanced cancerR01CA197103 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHENKER, YAEL · 2016 to 2021
$2.8M
Mentored Patient Oriented Research in Improving Surrogate Decision Making for Patients with Advanced Respiratory FailureK24HL148314 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Douglas B White · 2019 to 2026
$944k
Midcareer Investigator Award in Patient-Oriented Research: Yael Schenker, MD, MASK24AG070285 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHENKER, YAEL · 2021 to 2025
$841k
Promoting Safety by Engaging Diverse Diabetes Patients and their Caregivers in Secure MessagingK08HS027844 · AHRQ · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEMERE, WAGAHTA · 2021 to 2024
$591k
AHRQ HHS K08 HS027844NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA197103NHLBI NIH HHS K24 HL148314NIA NIH HHS K24 AG070285
6 · The paper itself

Abstract

contextPalliative care offers patient and family centered approaches that may mitigate risk of caregiver burden and poor mood.

objectivesTo determine whether a palliative care intervention (CONNECT) improved burden, mood, and self-efficacy among caregivers of patients with advanced cancer.

methodsIn this cluster randomized trial, patients and their caregivers were recruited from 17 Oncology clinics in Pennsylvania. Participants attended nurse-led monthly visits, addressing patient symptoms, goals of care, and advance care planning. At baseline and three months, we measured caregiver burden using Zarit Burden Interview (ZBI-12; range 0-48), caregiver anxiety and depression using Hospital Anxiety and Depression Scales (HADS-A, range 0-21; HADS-D, range 0-21). We measured caregiver self-efficacy at three months using Caregiver Inventory (CGI; range 0-189).

resultsWe enrolled 441 caregivers and 381 completed three-month assessments. We found no significant differences in caregiver burden (adjusted mean difference -0.39; 95% CI -1.07-0.29, P = 0.90), depression (adjusted mean difference -0.22, 95% CI -0.97-0.55, P = 0.26), or anxiety (adjusted mean difference 0.09; 95% CI -1.25-1.43, P = 0.58), between the intervention and standard care at three months. Caregiver self-efficacy was higher at three months in the intervention compared to standard care (adjusted mean difference 9.36; 95% CI 0.95-17.77, P = 0.030).

conclusionCaregivers in CONNECT did not experience improved burden or mood, however, they reported higher self-efficacy compared to caregivers receiving standard care. This study highlights the need for strategies to optimize caregiver outcomes in palliative care interventions.

Indexed as

CaregiversNeoplasmsHumansPalliative CarePatientsQuality of LifeAdvanced cancerCaregiver burdenCaregiver moodCaregiver self-efficacyPalliative care

Identifiers

PMID36503155
PMCPMC10191108

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.