ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023
The Association of Peripheral and Central Olfaction With Frailty in Older Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 14 citations in OpenAlex.
- Olfaction and muscle strength in older adults: a longitudinal study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Dysfunction in Olfactory Identification and Physical Function Decline in Older Adults.JAMA otolaryngology-- head & neck surgery · 2026Article
- Moving Beyond Odor Identification: Defining Olfactory Subdomain Cutoffs in Frailty Risk Assessment.International forum of allergy & rhinology · 2025Article
- Longitudinal Association of Olfactory Function with Frailty in Older Adults: The Atherosclerosis Risk in Communities Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Olfaction and diabetes among older adults.Chemical senses · 2025Article
- Global Poorer Olfaction, Frailty and Postoperative Adverse Outcomes: Exploring Their Interplay in a Prospective Cohort of Older Adults Undergoing Elective Surgery.Clinical interventions in aging · 2025Article
- The association between olfactory subdomains and frailty: A prospective case‒control study investigation.International forum of allergy & rhinology · 2024Article
- Reply to: Confounders in the association between olfactory subdomains and frailty.International forum of allergy & rhinology · 2024Article
- Olfactory Impairment and the Risk of Major Adverse Cardiovascular Outcomes in Older Adults.Journal of the American Heart Association · 2024Article
- Normative Data for the 12-Item Sniffin' Sticks Odor Identification Test in Older Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Olfaction and Mobility in Older Adults.JAMA otolaryngology-- head & neck surgery · 2024Article
- Ambient Air Pollutants and Olfaction among Women 50-79 Years of Age from the Sister Study.Environmental health perspectives · 2023Article
- Reimbursement for Olfactory Testing: A Growing Need at a Unique Time in History.JAMA otolaryngology-- head & neck surgery · 2023Article
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6 authors at 1 institution in 1 country.
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Abstract
backgroundOlfactory impairment is increasingly recognized as a biomarker of frailty, but the relationship between olfactory subdomains that describe peripheral or central dysfunction and frailty remains unexplored.
methodsWe examined 1 160 older adults from the National Social Life, Health, and Aging Project Wave 3. Olfactory identification (OI): the ability to identify an odorant; and olfactory sensitivity (OS): the ability to detect the presence of an odorant, were assessed using 5- and 6-point measures, respectively. Frailty was operationalized as both a 37-item frailty index (FI) and the 5-item Physical Frailty Phenotype (PFP). Mixed models were fit to examine the association between OI, OS, FI, and PFP, while adjusting for demographic and clinical covariates.
resultsParticipants in the most-frail PFP category had lower OI and OS scores (OI: 3.88 vs 4.19, p = .016; OS: 3.15 vs 3.47, p = .031), whereas participants in the most-frail FI category exhibited lower OI scores but not OS scores when compared to nonfrail participants (OI: 3.72 vs 4.27, p = .014; OS: 3.19 vs 3.43, p = .476). Adjusted mixed models showed that a point increase in OI was associated with a lower PFP score (β = -0.107, p = .006) and FI score (β = -0.009, p = .010). A point increase in OS was associated with a lower PFP score (β = -0.058, p = .016) but not FI score (β = -0.004, p = .064).
conclusionBoth OS and OI, predominantly peripheral and central measures of olfaction, respectively, are associated with frailty implicating olfaction as a potential biomarker and risk factor for frailty.
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