Evidence map›Paper›PMID 36502366›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2023

Assembly of Fillable Microrobotic Systems by Microfluidic Loading with Dip Sealing.

Rujie Sun, Xin Song, Kun Zhou, Yuyang Zuo, Richard Wang, Omar Rifaie-Graham, David J Peeler, Ruoxiao Xie, Yixuan Leng, Hongya Geng and 5 more

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. TOWARD CONTROLLED-RELEASE DRUG DELIVERY MICROCARRIERS ENABLED BY DIRECT LASER WRITING 3D PRINTING.Proceedings. IEEE International Conference on Micro Electro Mechanical Systems · 2024
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rujie SunDepartment of Materials, Imperial College London, London, SW7 2AZ, UK.
Xin SongDepartment of Materials, Imperial College London, London, SW7 2AZ, UK.
Kun ZhouDepartment of Materials, Imperial College London, London, SW7 2AZ, UK.
Yuyang ZuoDepartment of Bioengineering, Imperial College London, London, SW7 2AZ, UK.
Richard WangDepartment of Materials, Imperial College London, London, SW7 2AZ, UK.
Omar Rifaie-GrahamDepartment of Materials, Imperial College London, London, SW7 2AZ, UK.
David J PeelerDepartment of Materials, Imperial College London, London, SW7 2AZ, UK.ORCID https://orcid.org/0000-0003-2441-6409
Ruoxiao XieDepartment of Materials, Imperial College London, London, SW7 2AZ, UK.
Yixuan LengDepartment of Materials, Imperial College London, London, SW7 2AZ, UK.
Hongya GengInstitute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Giulia BrachiDepartment of Materials, Imperial College London, London, SW7 2AZ, UK.
Yun MaDepartment of Materials, Imperial College London, London, SW7 2AZ, UK.
Yutong LiuDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, SW7 2AZ, UK.
Lorna BarronDepartment of Materials, Imperial College London, London, SW7 2AZ, UK.
Molly M StevensDepartment of Materials, Imperial College London, London, SW7 2AZ, UK.ORCID https://orcid.org/0000-0002-1146-7090

Funding

Wellcome Trust 098411Wellcome Trust 098411/Z/12/Z
6 · The paper itself

Abstract

Microrobots can provide spatiotemporally well-controlled cargo delivery that can improve therapeutic efficiency compared to conventional drug delivery strategies. Robust microfabrication methods to expand the variety of materials or cargoes that can be incorporated into microrobots can greatly broaden the scope of their functions. However, current surface coating or direct blending techniques used for cargo loading result in inefficient loading and poor cargo protection during transportation, which leads to cargo waste, degradation and non-specific release. Herein, a versatile platform to fabricate fillable microrobots using microfluidic loading and dip sealing (MLDS) is presented. MLDS enables the encapsulation of different types of cargoes within hollow microrobots and protection of cargo integrity. The technique is supported by high-resolution 3D printing with an integrated microfluidic loading system, which realizes a highly precise loading process and improves cargo loading capacity. A corresponding dip sealing strategy is developed to encase and protect the loaded cargo whilst maintaining the geometric and structural integrity of the loaded microrobots. This dip sealing technique is suitable for different materials, including thermal and light-responsive materials. The MLDS platform provides new opportunities for microrobotic systems in targeted drug delivery, environmental sensing, and chemically powered micromotor applications.

Indexed as

environmental sensingfillable microroboticsmicrofluidicsmicromotorstargeted delivery

Identifiers

PMID36502366
PMCPMC7615483

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.