Evidence map›Paper›PMID 36502298›Full record

ArticleBreast disease2022

HPV-positive cervical squamous cell carcinoma metastasis to the breast, mimicking primary tumor.

Idam de Oliveira-Junior, Flávia Fazzio Barbin, Anapaula Hidemi Uema Watanabe, Ricardo Dos Reis, René Aloisio da Costa Vieira

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Breast disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Attributes of HPV associated cancers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  2. Metastatic Neoplasms to the Breast.International journal of surgical pathology · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Idam de Oliveira-JuniorPostgraduate Program in Tocogynecology, Medicine School - São Paulo State University (UNESP), São Paulo, SP, Brazil.
Flávia Fazzio BarbinDepartment of Pathology, Barretos Cancer Hospital, Barretos, SP, Brazil.
Anapaula Hidemi Uema WatanabeDepartment of Cancer Prevention, Barretos Cancer Hospital, Barretos, SP, Brazil.
Ricardo Dos ReisPostgraduate Program in Oncology, Barretos Cancer Hospital, Barretos, SP, Brazil.
René Aloisio da Costa VieiraPostgraduate Program in Tocogynecology, Medicine School - São Paulo State University (UNESP), São Paulo, SP, Brazil.
Hospital de Câncer de Barretos · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMetastatic disease to the breast is a rare condition, with contralateral breast metastasis being the most common primary site. CASE PRESENTATION: We present the case of a patient who underwent treatment for an HPV positive squamous cell carcinoma (SCC) of the cervix who, during follow-up, complained of a nodule in her left breast. Anatomopathological results indicating squamous carcinoma, which was not able to be differentiated from breast metaplastic carcinoma. Resection of the lesion was carried out, confirming carcinoma with squamous cell differentiation with negativity for GCDFP-15, mammaglobin, p63 and SOX10, but with positivity for p16 and for high risk HPV, confirming a single metastatic lesion of cervical carcinoma. DISCUSSION/

conclusionIn the presence of SCC in the breast, the differential diagnosis may consider the presence of primary lesion, metaplastic carcinoma with squamous cell differentiation or metastatic disease. The use of markers such as p63, SOX10 and p16, may help for a definitive diagnosis.

Indexed as

Breast NeoplasmsCarcinoma, Squamous CellPapillomavirus InfectionsUterine Cervical NeoplasmsBreastFemaleHumansbreast metastasisCervical cancerHPVmetastasis

Identifiers

PMID36502298
PMCPMC9881019
OpenAlexW4311677800

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.