Evidence map›Paper›PMID 36501773›Full record

ArticleSensors (Basel, Switzerland)2022

Assessing Corneal Endothelial Damage Using Terahertz Time-Domain Spectroscopy and Support Vector Machines.

Andrew Chen, Zachery B Harris, Arjun Virk, Azin Abazari, Kulandaiappan Varadaraj, Robert Honkanen, Mohammad Hassan Arbab

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrew ChenDepartment of Biomedical Engineering, Stony Brook University, 100 Nicolls Rd, Stony Brook, NY 11794, USA.
Zachery B HarrisDepartment of Biomedical Engineering, Stony Brook University, 100 Nicolls Rd, Stony Brook, NY 11794, USA.ORCID 0000-0002-6557-6225
Arjun VirkDepartment of Biomedical Engineering, Stony Brook University, 100 Nicolls Rd, Stony Brook, NY 11794, USA.
Azin AbazariDepartment of Ophthalmology, Renaissance School of Medicine, 101 Nicolls Rd, Stony Brook, NY 11794, USA.
Kulandaiappan VaradarajDepartment of Physiology and Biophysics, Renaissance School of Medicine, 101 Nicolls Rd, Stony Brook, NY 11794, USA.ORCID 0000-0003-2453-2741
Robert HonkanenDepartment of Ophthalmology, Renaissance School of Medicine, 101 Nicolls Rd, Stony Brook, NY 11794, USA.
Mohammad Hassan ArbabDepartment of Biomedical Engineering, Stony Brook University, 100 Nicolls Rd, Stony Brook, NY 11794, USA.ORCID 0000-0002-6565-3358
Stony Brook University · USStony Brook School · US

Funding

Noninvasive Broadband Terahertz Assessment of Burn SeverityR01GM112693 · NIGMS · UNIVERSITY OF WASHINGTON · PI ARBAB, M. HASSAN · 2015 to 2019
$2.6M
Roles of Lens Aquaporins and GPX1 in Hydrogen Peroxide Balance, Homeostasis, and AgingR01EY033346 · NEI · STATE UNIVERSITY NEW YORK STONY BROOK · PI Kulandaiappan Varadaraj · 2022 to 2026
$1.9M
Role of aquaporins in mammalian lens development,transparency and homeostasisR01EY026155 · NEI · STATE UNIVERSITY NEW YORK STONY BROOK · PI VARADARAJ, KULANDAIAPPAN · 2016 to 2019
$1.6M
NEI NIH HHS R01 EY026155NEI NIH HHS R01 EY033346NIGMS NIH HHS R01 GM112693NIGMS NIH HHS R01GM112693
6 · The paper itself

Abstract

The endothelial layer of the cornea plays a critical role in regulating its hydration by actively controlling fluid intake in the tissue via transporting the excess fluid out to the aqueous humor. A damaged corneal endothelial layer leads to perturbations in tissue hydration and edema, which can impact corneal transparency and visual acuity. We utilized a non-contact terahertz (THz) scanner designed for imaging spherical targets to discriminate between ex vivo corneal samples with intact and damaged endothelial layers. To create varying grades of corneal edema, the intraocular pressures of the whole porcine eye globe samples (

Indexed as

Corneal DiseasesTerahertz SpectroscopyAnimalsCorneaEdemaEndothelium, CornealSupport Vector MachineSwinecorneal edemacorneal endotheliumcorneal tissue hydrationintraocular pressureterahertz time domain spectroscopy

Identifiers

PMID36501773
PMCPMC9735956
OpenAlexW4309721157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.