Evidence map›Paper›PMID 36501237›Full record

ReviewPlants (Basel, Switzerland)2022

ER Stress and the Unfolded Protein Response: Homeostatic Regulation Coordinate Plant Survival and Growth.

June-Sik Kim, Keiichi Mochida, Kazuo Shinozaki

Open access · goldAbstract readReview
In one paragraph

Review in Plants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

June-Sik KimRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.ORCID 0000-0002-4703-609X
Keiichi MochidaRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.ORCID 0000-0003-1299-0024
Kazuo ShinozakiRIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan.
RIKEN Center for Sustainable Resource Science · JPOkayama University · JP

Funding

Japan Society for the Promotion of Science 21K05524
6 · The paper itself

Abstract

The endoplasmic reticulum (ER), a eukaryotic organelle, is the major site of protein biosynthesis. The disturbance of ER function by biotic or abiotic stress triggers the accumulation of misfolded or unfolded proteins in the ER. The unfolded protein response (UPR) is the best-studied ER stress response. This transcriptional regulatory system senses ER stress, activates downstream genes that function to mitigate stress, and restores homeostasis. In addition to its conventional role in stress responses, recent reports indicate that the UPR is involved in plant growth and development. In this review, we summarize the current knowledge of ER stress sensing and the activation and downstream regulation of the UPR. We also describe how the UPR modulates both plant growth and stress tolerance by maintaining ER homeostasis. Lastly, we propose that the UPR is a major component of the machinery that balances the trade-off between plant growth and survival in a dynamic environment.

Indexed as

defenseendoplasmic reticulum (ER)ER stressgene regulationreproductionstress responseunfolded protein response (UPR)vegetative growth

Identifiers

PMID36501237
PMCPMC9735958
OpenAlexW4309728723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.