Evidence map›Paper›PMID 36501163›Full record

ReviewNutrients2022

Behind the Scenes of Anthocyanins-From the Health Benefits to Potential Applications in Food, Pharmaceutical and Cosmetic Fields.

José S Câmara, Monica Locatelli, Jorge A M Pereira, Hélder Oliveira, Marco Arlorio, Iva Fernandes, Rosa Perestrelo, Victor Freitas, Matteo Bordiga

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. Pooled it
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  16. WildFoods (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

José S CâmaraCQM-Centro de Química da Madeira, Natural Products Research Group, Campus Universitário da Penteada, Universidade da Madeira, 9020-105 Funchal, Portugal.ORCID 0000-0003-1965-3151
Monica LocatelliDepartment of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale "A. Avogadro", Largo Donegani 2, 28100 Novara, Italy.ORCID 0000-0002-5297-6908
Jorge A M PereiraCQM-Centro de Química da Madeira, Natural Products Research Group, Campus Universitário da Penteada, Universidade da Madeira, 9020-105 Funchal, Portugal.ORCID 0000-0003-0316-5348
Hélder OliveiraLAQV, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal.ORCID 0000-0002-8256-2968
Marco ArlorioDepartment of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale "A. Avogadro", Largo Donegani 2, 28100 Novara, Italy.
Iva FernandesLAQV, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal.ORCID 0000-0003-2297-0086
Rosa PerestreloCQM-Centro de Química da Madeira, Natural Products Research Group, Campus Universitário da Penteada, Universidade da Madeira, 9020-105 Funchal, Portugal.ORCID 0000-0002-7223-1022
Victor FreitasLAQV, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal.
Matteo BordigaDepartment of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale "A. Avogadro", Largo Donegani 2, 28100 Novara, Italy.ORCID 0000-0001-6587-9843
Universidade da Madeira · PTUniversidade do Porto · PTUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · IT

Funding

ARDITI-Agência Regional para o Desenvolvimento da Investigação Tecnologia e Inovação M1420-01-0145-FEDER-000005FCT-Fundação para a Ciência e a Tecnologia CQM Base Fund UIDB/00674/2020FCT-Fundação para a Ciência e a Tecnologia Programmatic Fund UIDP/00674/2020Interreg MAC 2014-2020 MAC2/1.1b/350 - AD4MACPROEQUIPRAM program M1420-01-0145-FEDER-000008
6 · The paper itself

Abstract

Anthocyanins are widespread and biologically active water-soluble phenolic pigments responsible for a wide range of vivid colours, from red (acidic conditions) to purplish blue (basic conditions), present in fruits, vegetables, and coloured grains. The pigments' stability and colours are influenced mainly by pH but also by structure, temperature, and light. The colour-stabilizing mechanisms of plants are determined by inter- and intramolecular co-pigmentation and metal complexation, driven by van der Waals, π-π stacking, hydrogen bonding, and metal-ligand interactions. This group of flavonoids is well-known to have potent anti-inflammatory and antioxidant effects, which explains the biological effects associated with them. Therefore, this review provides an overview of the role of anthocyanins as natural colorants, showing they are less harmful than conventional colorants, with several technological potential applications in different industrial fields, namely in the textile and food industries, as well as in the development of photosensitizers for dye-sensitized solar cells, as new photosensitizers in photodynamic therapy, pharmaceuticals, and in the cosmetic industry, mainly on the formulation of skin care formulations, sunscreen filters, nail colorants, skin & hair cleansing products, amongst others. In addition, we will unveil some of the latest studies about the health benefits of anthocyanins, mainly focusing on the protection against the most prevalent human diseases mediated by oxidative stress, namely cardiovascular and neurodegenerative diseases, cancer, and diabetes. The contribution of anthocyanins to visual health is also very relevant and will be briefly explored.

Indexed as

AnthocyaninsCosmeticsFruitHumansPharmaceutical PreparationsPigmentationVegetablesAnthocyaninsCosmeticsPharmaceutical Preparationsanthocyanins (ACNs)bioactivitycosmetic applicationsfood applicationshealth benefitsoccurrencepharmaceutical applications

Identifiers

PMID36501163
PMCPMC9738495
OpenAlexW4310681509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.