Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors at 6 institutions in 2 countries.
Larissa de Oliveira Passos JesusInterdisciplinary Center for Biochemical Research, University of Mogi das Cruzes (UMC), Mogi das Cruzes 08780-911, SP, Brazil.
Aline Aparecida de SouzaInterdisciplinary Center for Biochemical Research, University of Mogi das Cruzes (UMC), Mogi das Cruzes 08780-911, SP, Brazil.
Heron Fernandes Vieira TorquatoFaculty of Pharmacy, Centro Universitário Braz Cubas (UBC), Mogi das Cruzes 08773-380, SP, Brazil.
Vanessa Silva GontijoPhytochemistry and Medicinal Chemistry Laboratory (LFQM), Institute of Chemistry, Federal University of Alfenas (UNIFAL), Alfenas 37130-000, MG, Brazil.ORCID 0000-0003-1674-818X
Rossimirian Pereira de FreitasInstitute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.
Tarsis Ferreira GesteiraCollege of Optometry, University of Houston, Houston, TX 77204, USA.
Vivien Jane Coulson-ThomasCollege of Optometry, University of Houston, Houston, TX 77204, USA.ORCID 0000-0002-5848-0225
Ricardo José Soares TorquatoDepartment of Biochemistry, Federal University of São Paulo, São Paulo (UNIFESP), São Paulo 04044-020, SP, Brazil.
Aparecida Sadae TanakaDepartment of Biochemistry, Federal University of São Paulo, São Paulo (UNIFESP), São Paulo 04044-020, SP, Brazil.
Edgar Julian Paredes-GameroFaculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil.ORCID 0000-0003-3686-8402
Wagner Alves de Souza JudiceInterdisciplinary Center for Biochemical Research, University of Mogi das Cruzes (UMC), Mogi das Cruzes 08780-911, SP, Brazil.ORCID 0000-0002-1608-9105
Universidade de Mogi das Cruzes · BRUniversidade Federal de Mato Grosso do Sul · BRUniversidade Federal de São Paulo · BRUniversity of Houston · USUniversidade Federal de Alfenas · BRUniversidade Federal de Minas Gerais · BR
Funding
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) Finance Code 001Fundação de Amparo e Pesquisa do Estado de São Paulo-FAPESP 2014/02205-1Fundação de Amparo e Pesquisa do Estado de São Paulo-FAPESP 2016/25112-4Fundação de Amparo e Pesquisa do Estado de São Paulo-FAPESP 2021/01503-2Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (Fundect) PPSUS 08/2020
6 · The paper itself
Abstract
This study investigates the efficacy of miltefosine, alkylphospholipid, and alkyltriazolederivative compounds against leukemia lineages. The cytotoxic effects and cellular and molecular mechanisms of the compounds were investigated. The inhibitory potential and mechanism of inhibition of cathepsins B and L, molecular docking simulation, molecular dynamics and binding free energy evaluation were performed to determine the interaction of cathepsins and compounds. Among the 21 compounds tested,
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
In Vitro Study of Cytotoxic Mechanisms of Alkylphospholipids and Alkyltriazoles in Acute Lymphoblastic Leukemia Models. · full record | OpenQuestion