ReviewMolecules (Basel, Switzerland)2022
Advances in Atroposelectively De Novo Synthesis of Axially Chiral Heterobiaryl Scaffolds.
Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Organocatalyzed diastereo- and enantioselective synthesis of N-N atropisomeric isoindolinones bearing central chirality.Nature communications · 2025Article
- Catalytic asymmetric reactions of isocyanides for constructing non-central chirality.Beilstein journal of organic chemistry · 2025Article
- Cobaltaelectro-Catalyzed C-H Annulation with Allenes for Atropochiral andACS catalysis · 2023Article
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Authors and funding
4 authors.
Funding
Abstract
Axially chiral heterobiaryl frameworks are privileged structures in many natural products, pharmaceutically active molecules, and chiral ligands. Therefore, a variety of approaches for constructing these skeletons have been developed. Among them, de novo synthesis, due to its highly convergent and superior atom economy, serves as a promising strategy to access these challenging scaffolds including C-N, C-C, and N-N chiral axes. So far, several elegant reviews on the synthesis of axially chiral heterobiaryl skeletons have been disclosed, however, atroposelective construction of the heterobiaryl subunits by de novo synthesis was rarely covered. Herein, we summarized the recent advances in the catalytic asymmetric synthesis of the axially chiral heterobiaryl scaffold via de novo synthetic strategies. The related mechanism, scope, and applications were also included.
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