Evidence map›Paper›PMID 36500605›Full record

ArticleMolecules (Basel, Switzerland)2022

Cholinesterases Inhibition, Anticancer and Antioxidant Activity of Novel Benzoxazole and Naphthoxazole Analogs.

Alicja Skrzypek, Monika Karpińska, Małgorzata Juszczak, Aneta Grabarska, Joanna Wietrzyk, Elżbieta Krajewska-Kułak, Marek Studziński, Tadeusz Paszko, Joanna Matysiak

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alicja SkrzypekDepartment of Chemistry, University of Life Sciences, Akademicka 15, 20-950 Lublin, Poland.ORCID 0000-0002-6740-7142
Monika KarpińskaInstitute of Industrial Organic Chemistry, Łukasiewicz Research Network, Annopol 6, 03-236 Warsaw, Poland.
Małgorzata JuszczakDepartment of Medical Biology, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland.
Aneta GrabarskaDepartment of Biochemistry and Molecular Biology, Medical University, Chodźki 1, 20-090 Lublin, Poland.
Joanna WietrzykDepartment of Experimental Oncology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114 Wroclaw, Poland.ORCID 0000-0003-4980-6606
Elżbieta Krajewska-KułakDepartment of Integrated Medical Care, Medical University, M. Skłodowska-Curie 7A, 15-094 Białystok, Poland.
Marek StudzińskiDepartment of Physical Chemistry, Institute of Chemistry, Faculty of Chemistry, Maria Curie-Skłodowska University, Pl. M. C. Skłodowkiej 3, 20-031 Lublin, Poland.ORCID 0000-0001-8226-1922
Tadeusz PaszkoDepartment of Chemistry, University of Life Sciences, Akademicka 15, 20-950 Lublin, Poland.ORCID 0000-0002-2864-2211
Joanna MatysiakDepartment of Chemistry, University of Life Sciences, Akademicka 15, 20-950 Lublin, Poland.ORCID 0000-0002-0363-4450

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Benzoxazole and naphthoxazole fused systems are found in many biologically active molecules. Novel benzoxazole and naphthoxazole analogs functionalized by the 2,4-dihydroxyphenyl moiety were designed, obtained and evaluated as a broad spectrum of biological potency compounds. Sulfinylbis[(2,4-dihydroxyphenyl)methanethione] or its analogs and 2-aminophenols or 1-amino-2-naphthol were used as starting reagents. 4-(Naphtho[1,2-

Indexed as

BenzoxazolesCholinesterase InhibitorsAcetylcholinesteraseAntioxidantsHumansMolecular Docking SimulationMolecular StructureOxazolesStructure-Activity RelationshipAcetylcholinesteraseAntioxidantsBenzoxazolesCholinesterase InhibitorsOxazolesacetylcholinesteraseantioxidantantiproliferative activitybenzoxazolebutyrylcholinesterasenaphthoxazole

Identifiers

PMID36500605
PMCPMC9738531

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.