Evidence map›Paper›PMID 36500515›Full record

ReviewMolecules (Basel, Switzerland)2022

Advances in Molecular Pathology of Obstructive Sleep Apnea.

Menghan Zhang, Yun Lu, Lu Sheng, Xinxin Han, Liming Yu, Weihua Zhang, Shangfeng Liu, Yuehua Liu

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Menghan Zhang *Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, China.
Yun Lu *Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, China.
Lu Sheng *Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, China.ORCID 0000-0001-9991-5283
Xinxin HanShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, China.
Liming YuShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, China.
Weihua ZhangShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, China.
Shangfeng LiuShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, China.ORCID 0000-0002-2413-3946
Yuehua LiuShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, China.
Fudan University · CN

Funding

National Science Foundation of Shanghai 19411961900Shanghai Health Commission Funds for Young Scientists 20164Y0031Shanghai Municipal Commission of Health and Family Planning Priority Projects 201640023Shanghai Stomatological Hospital Talent Project SSDC-2019-RC01Shanghai Talent Development Funding, Shanghai Wumengchao Medical Science Foundation JJHXM-2019018the National Natural Science Foundation of China 81771109, 21703031, 81600897, 81901031Three-year Action Plan for Promoting Clinical Skills and Innovation in Municipal Hospital 16CR2044B
6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) is a common syndrome that features a complex etiology and set of mechanisms. Here we summarized the molecular pathogenesis of OSA, especially the prospective mechanism of upper? airway dilator fatigue and the current breakthroughs. Additionally, we also introduced the molecular mechanism of OSA in terms of related studies on the main signaling pathways and epigenetics alterations, such as microRNA, long non-coding RNA, and DNA methylation. We also reviewed small molecular compounds, which are potential targets for gene regulations in the future, that are involved in the regulation of OSA. This review will be beneficial to point the way for OSA research within the next decade.

Indexed as

MicroRNAsSleep Apnea, ObstructiveDNA MethylationEpigenesis, GeneticHumansPathology, MolecularSleepMicroRNAsmolecular pathogenesisobstructive sleep apneapharyngeal muscle fatiguesignaling pathways

Identifiers

PMID36500515
PMCPMC9739159
OpenAlexW4311102304

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.