Evidence map›Paper›PMID 36500437›Full record

ArticleMolecules (Basel, Switzerland)2022

Lewis Acid-Catalyzed 2,3-Dihydrofuran Acetal Ring-Opening Benzannulations toward Functionalized 1-Hydroxycarbazoles.

Shaoren Yuan, Gabriel Guerra Faura, Hailey E Areheart, Natalie E Peulen, Stefan France

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shaoren YuanGeorgia Institute of Technology, School of Chemistry and Biochemistry, Atlanta, GA 30332, USA.
Gabriel Guerra FauraGeorgia Institute of Technology, School of Chemistry and Biochemistry, Atlanta, GA 30332, USA.
Hailey E AreheartGeorgia Institute of Technology, School of Chemistry and Biochemistry, Atlanta, GA 30332, USA.
Natalie E PeulenGeorgia Institute of Technology, School of Chemistry and Biochemistry, Atlanta, GA 30332, USA.
Stefan FranceGeorgia Institute of Technology, School of Chemistry and Biochemistry, Atlanta, GA 30332, USA.ORCID 0000-0001-5998-6167
Georgia Institute of Technology · US

Funding

Georgia Institute of Technology Leddy Family FellowshipNational Science Foundation CHE-2102472
6 · The paper itself

Abstract

The development of a Lewis acid-catalyzed, intramolecular ring-opening benzannulation of 5-(indolyl)2,3-dihydrofuran acetals is described. The resulting 1-hydroxycarbazole-2-carboxylates are formed in up to 90% yield in 1 h. The dihydrofuran acetals are readily accessed from the reactions of enol ethers and α-diazo-β-indolyl-β-ketoesters. To highlight the method's synthetic utility, a formal total synthesis of murrayafoline A, a bioactive carbazole-containing natural product, was undertaken.

Indexed as

AcetalsLewis AcidsCarboxylic AcidsEthersAcetalsCarboxylic AcidsEthersLewis Acidsbenzannulationcarbazolesdihydrofuran acetalsring-opening cyclizationssynthetic methods

Identifiers

PMID36500437
PMCPMC9737012
OpenAlexW4310382815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.