Evidence map›Paper›PMID 36500302›Full record

ArticleMolecules (Basel, Switzerland)2022

Antioxidant, Antimicrobial, Cytotoxicity, and Larvicidal Activities of Selected Synthetic Bis-Chalcones.

Aswathi Moothakoottil Kuttithodi, Divakaran Nikhitha, Jisha Jacob, Arunaksharan Narayanankutty, Manoj Mathews, Opeyemi Joshua Olatunji, Rajakrishnan Rajagopal, Ahmed Alfarhan, Damia Barcelo

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aswathi Moothakoottil KuttithodiMolecular Microbial Ecology Lab, PG and Research Department of Zoology, St. Joseph's College (Autonomous), Devagiri, Calicut 680 555, Kerala, India.ORCID 0000-0002-5482-8108
Divakaran NikhithaMolecular Microbial Ecology Lab, PG and Research Department of Zoology, St. Joseph's College (Autonomous), Devagiri, Calicut 680 555, Kerala, India.
Jisha JacobMolecular Microbial Ecology Lab, PG and Research Department of Zoology, St. Joseph's College (Autonomous), Devagiri, Calicut 680 555, Kerala, India.
Arunaksharan NarayanankuttyDivision of Cell and Molecular Biology, PG and Research Department of Zoology, St. Joseph's College (Autonomous), Devagiri, Calicut 673 008, Kerala, India.ORCID 0000-0002-6232-1665
Manoj MathewsPG and Research Department of Chemistry, St. Joseph's College (Autonomous), Devagiri, Calicut 673 008, Kerala, India.ORCID 0000-0003-3020-4808
Opeyemi Joshua OlatunjiAfrican Genome Center, Mohammed VI Polytechnic University, Ben Guerir 43150, Morocco.ORCID 0000-0002-6800-4919
Rajakrishnan RajagopalDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Ahmed AlfarhanDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Damia BarceloWater and Soil Research Group, Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plants are known to have numerous phytochemicals and other secondary metabolites with numerous pharmacological and biological properties. Among the various compounds, polyphenols, flavonoids, anthocyanins, alkaloids, and terpenoids are the predominant ones that have been explored for their biological potential. Among these, chalcones and bis-chalcones are less explored for their biological potential under in vitro experiments, cell culture models, and animal studies. In the present study, we evaluated six synthetic bis-chalcones that were different in terms of their aromatic cores, functional group substitution, and position of substitutions. The results indicated a strong antioxidant property in terms of DPPH and ABTS radical-scavenging potentials and ferric-reducing properties. In addition, compounds

Indexed as

Anti-Infective AgentsChalconesAnimalsAnthocyaninsAnti-Bacterial AgentsAntioxidantsEscherichia coliMicrobial Sensitivity TestsPlant ExtractsAnthocyaninsAnti-Bacterial AgentsAnti-Infective AgentsAntioxidantsChalconesPlant Extractsantimicrobial activityantioxidant activitybis-chalconeschemical structurelarvicidal activity

Identifiers

PMID36500302
PMCPMC9740027

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.