Evidence map›Paper›PMID 36500256›Full record

ArticleMolecules (Basel, Switzerland)2022

Eleonora Gianquinto, Federica Sodano, Barbara Rolando, Magdalena Kostrzewa, Marco Allarà, Ali Mokhtar Mahmoud, Poulami Kumar, Francesca Spyrakis, Alessia Ligresti, Konstantin Chegaev

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Eleonora GianquintoDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Federica SodanoDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.ORCID 0000-0003-2013-4893
Barbara RolandoDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.ORCID 0000-0001-6138-1503
Magdalena KostrzewaNational Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.ORCID 0000-0002-3395-5191
Marco AllaràNational Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Ali Mokhtar MahmoudNational Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.ORCID 0000-0003-2328-0060
Poulami KumarNational Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Francesca SpyrakisDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.ORCID 0000-0002-4016-227X
Alessia LigrestiNational Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.ORCID 0000-0003-1787-3900
Konstantin ChegaevDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.ORCID 0000-0001-9962-1218
National Research Council · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cannabinoid type 1 (hCB1) and type 2 (hCB2) receptors are pleiotropic and crucial targets whose signaling contributes to physiological homeostasis and its restoration after injury. Being predominantly expressed in peripheral tissues, hCB2R represents a safer therapeutic target than hCB1R, which is highly expressed in the brain, where it regulates processes related to cognition, memory, and motor control. The development of hCB2R ligands represents a therapeutic opportunity for treating diseases such as pain, inflammation and cancer. Identifying new selective scaffolds for cannabinoids and determining the structural determinants responsible for agonism and antagonism are priorities in drug design. In this work, a series of

Indexed as

Cannabinoid Receptor AgonistsCannabinoidsHumansLigandsProtein BindingReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Structure-Activity RelationshipSulfonamidesCannabinoid Receptor AgonistsCannabinoidsLigandsReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Sulfonamidescannabinoid receptorsdrug designhCB2R selective ligandsin silico simulationsmechanism of receptor activation

Identifiers

PMID36500256
PMCPMC9738591
OpenAlexW4309848012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.