Evidence map›Paper›PMID 36500251›Full record

ArticleMolecules (Basel, Switzerland)2022

A New MBH Adduct as an Efficient Ligand in the Synthesis of Metallodrugs: Characterization, Geometrical Optimization, XRD, Biological Activities, and Molecular Docking Studies.

Shazia Ishfaq, Shazia Nisar, Sadaf Iqbal, Saqib Ali, Syed Tariq Ali, ElSayed Din, Norah Salem Alsaiari, Kholood A Dahlous, Muhammad Sufyan Javed, Patrizia Bocchetta

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 5 countries.

Shazia IshfaqDepartment of Chemistry, Faculty of Sciences, University of Karachi, Karachi 75270, Pakistan.
Shazia NisarDepartment of Chemistry, Faculty of Sciences, University of Karachi, Karachi 75270, Pakistan.ORCID 0000-0002-0996-7029
Sadaf IqbalDepartment of Chemistry, Faculty of Sciences, University of Karachi, Karachi 75270, Pakistan.
Saqib AliDepartment of Chemistry, Faculty of Basic and Applied Sciences, University of Kotli, Kotli 11100, Pakistan.ORCID 0000-0002-5397-7101
Syed Tariq AliDepartment of Chemistry, Faculty of Sciences, University of Karachi, Karachi 75270, Pakistan.ORCID 0000-0002-7443-4376
ElSayed DinFaculty of Engineering and Technology, Future University in Egypt, New Cairo 11835, Egypt.ORCID 0000-0002-0229-0705
Norah Salem AlsaiariDepartment of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.ORCID 0000-0001-9123-2453
Kholood A DahlousDepartment of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Muhammad Sufyan JavedSchool of Physical Science and Technology, Lanzhou University, Lanzhou 730000, China.ORCID 0000-0002-2771-0251
Patrizia BocchettaDipartimento di Ingegneria dell'Innovazione, Università del Salento, via Monteroni, 73100 Lecce, Italy.ORCID 0000-0002-6845-1620
University of Karachi · PKFuture University in Egypt · EGKing Saud University · SALanzhou University · CNPrincess Nourah bint Abdulrahman University · SAUniversity of Salento · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article reports the synthesis, characterization, geometrical optimization, and biological studies of new MBH-based organometallic compounds of medicinal significance. The ligand (MNHA) was prepared via the Morita-Baylis-Hillman (MBH) synthetic route, from aromatic aldehyde containing multiple functional groups. Metal complexes were prepared in an alkaline medium and under other suitable reaction conditions. Spectral and elemental analyses were used to identify the structural and molecular formulas of each compound. Optimized geometry was determined through density functional theory (DFT) B3LYP and 6-311++ G (d,p) basis set for the MBH adduct, whereas structures of novel complexes were optimized with the semi-empirical PM6 method. Powder XRD analysis furnished the crystal class of complexes, with Co

Indexed as

Coordination ComplexesStaphylococcus aureusEscherichia coliLigandsMicrobial Sensitivity TestsMolecular Docking SimulationSchiff BasesCoordination ComplexesLigandsSchiff Basesbiological studiesgeometrical optimizationMBH adductmetal complexesXRD

Identifiers

PMID36500251
PMCPMC9735827
OpenAlexW4309848164

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.