Evidence map›Paper›PMID 36500248›Full record

ArticleMolecules (Basel, Switzerland)2022

Excited-State Dynamics of Proflavine after Intercalation into DNA Duplex.

Jie Zhou, Yanyan Jia, Xueli Wang, Menghui Jia, Haifeng Pan, Zhenrong Sun, Jinquan Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Impacting the balance between COChemical science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jie ZhouState Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200241, China.
Yanyan JiaKey Laboratory for Advanced Materials, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.
Xueli WangState Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200241, China.
Menghui JiaState Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200241, China.
Haifeng PanState Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200241, China.
Zhenrong SunState Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200241, China.
Jinquan ChenState Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200241, China.ORCID 0000-0003-0652-1379
East China Normal University · CNEast China University of Science and Technology · CNShanxi University · CN

Funding

National Nature Science foundation of China 61720106009National Nature Science foundation of China 91850202National Nature Science foundation of China 92156024National Nature Science Foundation of China 21873030
6 · The paper itself

Abstract

Proflavine is an acridine derivative which was discovered as one of the earliest antibacterial agents, and it has been proven to have potential application to fields such as chemotherapy, photobiology and solar-energy conversion. In particular, it is well known that proflavine can bind to DNA with different modes, and this may open addition photochemical-reaction channels in DNA. Herein, the excited-state dynamics of proflavine after intercalation into DNA duplex is studied using femtosecond time-resolved spectroscopy, and compared with that in solution. It is demonstrated that both fluorescence and the triplet excited-state generation of proflavine were quenched after intercalation into DNA, due to ultrafast non-radiative channels. A static-quenching mechanism was identified for the proflavine-DNA complex, in line with the spectroscopy data, and the excited-state deactivation mechanism was proposed.

Indexed as

Intercalating AgentsProflavineAcridinesDNAAcridinesDNAIntercalating AgentsProflavineDNA duplexexcited-state dynamicsfemtosecond transient-absorptionfluorescence-quenchingproflavine

Identifiers

PMID36500248
PMCPMC9738913
OpenAlexW4310038931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.