Evidence map›Paper›PMID 36499764›Full record

ArticleInternational journal of molecular sciences2022

Role of Monovalent Ions in the NKCC1 Inhibition Mechanism Revealed through Molecular Simulations.

Pavel Janoš, Alessandra Magistrato

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Pavel JanošCNR-IOM c/o International School for Advanced Studies (SISSA/ISAS), Via Bonomea 265, 34136 Trieste, Italy.ORCID 0000-0002-9068-2652
Alessandra MagistratoCNR-IOM c/o International School for Advanced Studies (SISSA/ISAS), Via Bonomea 265, 34136 Trieste, Italy.ORCID 0000-0002-2003-1985
Scuola Internazionale Superiore di Studi Avanzati · IT

Funding

Friuli Venezia Giulia Region D93D19000020007 POR FESR 2014 2020-1.3.bItalian Association for Cancer Research 24514
6 · The paper itself

Abstract

The secondary active Na-K-Cl cotransporter 1 (NKCC1) promotes electroneutral uptake of two chloride ions, one sodium ion and one potassium ion. NKCC1 regulates Cl

Indexed as

BumetanideZebrafishAnimalsChloridesHumansK Cl- CotransportersPotassiumSodiumSolute Carrier Family 12, Member 2BumetanideChloridesK Cl- CotransportersPotassiumSodiumSolute Carrier Family 12, Member 2drug designdynamic dockingenhanced samplingion transportersmembrane transportersmolecular dynamicsmonovalent ions

Identifiers

PMID36499764
PMCPMC9741434
OpenAlexW4311160273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.