Evidence map›Paper›PMID 36499693›Full record

ArticleInternational journal of molecular sciences2022

TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by

Rocco Cappellesso, Lorenzo Nicolè, Paolo Del Fiore, Luisa Barzon, Alessandro Sinigaglia, Silvia Riccetti, Renato Franco, Federica Zito Marino, Giada Munari, Carolina Zamuner and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Rocco CappellessoPathological Anatomy Unit, Padua University Hospital, 35121 Padua, Italy.ORCID 0000-0002-0480-3412
Lorenzo NicolèDepartment of Pathology, Angelo Hospital, 30174 Venice, Italy.ORCID 0000-0001-8126-9674
Paolo Del FioreSoft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0002-2862-8014
Luisa BarzonDepartment of Molecular Medicine (DMM), University of Padua, 35121 Padua, Italy.ORCID 0000-0003-0720-8456
Alessandro SinigagliaDepartment of Molecular Medicine (DMM), University of Padua, 35121 Padua, Italy.
Silvia RiccettiDepartment of Molecular Medicine (DMM), University of Padua, 35121 Padua, Italy.
Renato FrancoPathology Unit, University of Campania "L. Vanvitelli", 80129 Naples, Italy.
Federica Zito MarinoPathology Unit, University of Campania "L. Vanvitelli", 80129 Naples, Italy.
Giada MunariVeneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Carolina ZamunerVeneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Francesco CavallinIndependent Statistician, 36020 Solagna, Italy.ORCID 0000-0002-0831-3971
Marta SbaragliaDepartment of Medicine (DIMED), University of Padua, 35121 Padua, Italy.
Francesca GaluppiniDepartment of Medicine (DIMED), University of Padua, 35121 Padua, Italy.ORCID 0000-0002-3245-2322
Franco BassettoDepartment of Neurosciences (DNS), University of Padua, 35128 Padua, Italy.
Mauro AlaibacDepartment of Medicine (DIMED), University of Padua, 35121 Padua, Italy.
Vanna Chiarion-SileniMelanoma Unit, Oncology 2 Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0001-9191-9124
Luisa PiccinMelanoma Unit, Oncology 2 Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Clara BennaDepartment of Surgery, Oncology and Gastroenterology (DISCOG), University of Padua, 35128 Padua, Italy.ORCID 0000-0002-9077-2471
Matteo FassanDepartment of Medicine (DIMED), University of Padua, 35121 Padua, Italy.ORCID 0000-0001-6515-5482
Simone MocellinSoft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Angelo Paolo Dei TosDepartment of Medicine (DIMED), University of Padua, 35121 Padua, Italy.
University of Padua · ITIstituto Oncologico Veneto · ITUniversity of Campania "Luigi Vanvitelli" · ITIstituto Nazionale di Statistica · IT

Funding

Veneto Institute of Oncology (IOV)-I.R.C.C.S project 5x1000, section Sinergia, title PROSOFT
6 · The paper itself

Abstract

Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation, with a rapidly growing incidence rate, high risk of recurrence, and aggressive behavior. The available therapeutic options for advanced disease are limited and there is a pressing need for new treatments. Tumors harboring fusions involving one of the neurotrophin receptor tyrosine kinase (

Indexed as

Carcinoma, Merkel CellNeoplasmsSkin NeoplasmsBiomarkers, TumorHumansNerve Growth FactorsOncogene Proteins, FusionReceptor, trkAReceptor, trkCBiomarkers, TumorNerve Growth FactorsOncogene Proteins, FusionReceptor, trkAReceptor, trkCEPR17341Merkel cell carcinomaNTRK1NTRK2NTRK3

Identifiers

PMID36499693
PMCPMC9737899
OpenAlexW4311633698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.