Evidence map›Paper›PMID 36499661›Full record

ArticleInternational journal of molecular sciences2022

Locus Coeruleus Neurons' Firing Pattern Is Regulated by ERG Voltage-Gated K

Sonia Hasan, Francis Delicata, Leonardo Guasti, Claudia Duranti, Fatemah Mousalem Haidar, Annarosa Arcangeli, Paola Imbrici, Mauro Pessia, Mario Valentino, Maria Cristina D'Adamo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Ethnobotany-guided exploration of plant-derived photosensitizer candidates for photodynamic therapy.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Review
  2. Article
  3. Modulation ofInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sonia HasanDepartment of Physiology, Faculty of Medicine, Kuwait University, Safat 13110, Kuwait.ORCID 0000-0003-3359-8208
Francis DelicataCollege of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada.ORCID 0000-0002-5339-5275
Leonardo GuastiCentre for Endocrinology, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.ORCID 0000-0002-4616-6044
Claudia DurantiDepartment of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, 50121 Firenze, Italy.
Fatemah Mousalem HaidarDepartment of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab Emirates.
Annarosa ArcangeliDepartment of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, 50121 Firenze, Italy.
Paola ImbriciDepartment of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0001-9140-5350
Mauro PessiaDepartment of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab Emirates.ORCID 0000-0002-2857-6795
Mario ValentinoDepartment of Physiology & Biochemistry, Faculty of Medicine & Surgery, University of Malta, MSD 2080 Msida, Malta.ORCID 0000-0001-8196-1345
Maria Cristina D'AdamoDepartment of Medicine & Surgery, LUM University "Giuseppe Degennaro", Casamassima, 70010 Bari, Italy.ORCID 0000-0002-6758-6064

Funding

Malta Council for Science and Technology R&I-2017-029T BooKindThe Alfred Mizzi Foundation Malta E17L077United Arab Emirates University 21M149United Arab Emirates University 31M452United Arab Emirates University 31M468
6 · The paper itself

Abstract

Locus coeruleus (LC) neurons, with their extensive innervations throughout the brain, control a broad range of physiological processes. Several ion channels have been characterized in LC neurons that control intrinsic membrane properties and excitability. However, ERG (

Indexed as

Ether-A-Go-Go Potassium ChannelsLocus CoeruleusAction PotentialsAnimalsAnti-Arrhythmia AgentsMiceNeuronsAnti-Arrhythmia AgentsEther-A-Go-Go Potassium Channelsclass III anti-arrhythmic drugERG K+ channelsether-à-go-go–related genelocus coeruleus neuronsnoradrenergic systemWAY-123,398

Identifiers

PMID36499661
PMCPMC9738708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.