Evidence map›Paper›PMID 36499648›Full record

ArticleInternational journal of molecular sciences2022

Radiomic Features Applied to Contrast Enhancement Spectral Mammography: Possibility to Predict Breast Cancer Molecular Subtypes in a Non-Invasive Manner.

Luca Nicosia, Anna Carla Bozzini, Daniela Ballerini, Simone Palma, Filippo Pesapane, Sara Raimondi, Aurora Gaeta, Federica Bellerba, Daniela Origgi, Paolo De Marco and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Luca NicosiaBreast Imaging Division, Radiology Department, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0003-3979-8075
Anna Carla BozziniBreast Imaging Division, Radiology Department, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy.
Daniela BalleriniBreast Radiology, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milano, Italy.
Simone PalmaDepartment of Radiological and Hematological Sciences, Catholic University of the Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy.ORCID 0000-0002-8824-2535
Filippo PesapaneBreast Imaging Division, Radiology Department, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-0374-5054
Sara RaimondiMolecular and Pharmaco-Epidemiology Unit, Department of Experimental Oncology, IEO IRCCS, 20139 Milan, Italy.ORCID 0000-0003-4673-9049
Aurora GaetaMolecular and Pharmaco-Epidemiology Unit, Department of Experimental Oncology, IEO IRCCS, 20139 Milan, Italy.
Federica BellerbaMolecular and Pharmaco-Epidemiology Unit, Department of Experimental Oncology, IEO IRCCS, 20139 Milan, Italy.ORCID 0000-0002-5956-4340
Daniela OriggiMedical Physics Unit, IEO European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy.
Paolo De MarcoMedical Physics Unit, IEO European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy.
Giuseppe Castiglione MinischettiMedical Physics Unit, IEO European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy.
Claudia SangalliData Management, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Lorenza MeneghettiBreast Imaging Division, Radiology Department, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy.
Giuseppe CuriglianoDepartment of Oncology and Hemato-Oncology, University of Milano, 20122 Milano, Italy.ORCID 0000-0003-1781-2518
Enrico CassanoBreast Imaging Division, Radiology Department, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-3437-8939
European Institute of Oncology · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITRipamonti · ITUniversity of Milan · ITData Management (Italy) · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to investigate the association between the radiomic features of contrast-enhanced spectral mammography (CESM) images and a specific receptor pattern of breast neoplasms. In this single-center retrospective study, we selected patients with neoplastic breast lesions who underwent CESM before a biopsy and surgical assessment between January 2013 and February 2022. Radiomic analysis was performed on regions of interest selected from recombined CESM images. The association between the features and each evaluated endpoint (ER, PR, Ki-67, HER2+, triple negative, G2-G3 expressions) was investigated through univariate logistic regression. Among the significant and highly correlated radiomic features, we selected only the one most associated with the endpoint. From a group of 321 patients, we enrolled 205 malignant breast lesions. The median age at the exam was 50 years (interquartile range (IQR) 45-58). NGLDM_Contrast was the only feature that was positively associated with both ER and PR expression (

Indexed as

Breast NeoplasmsContrast MediaFemaleHumansKi-67 AntigenMammographyMiddle AgedRetrospective StudiesContrast MediaKi-67 Antigenbreast cancerCESMmolecular subtypesradiomics

Identifiers

PMID36499648
PMCPMC9740943
OpenAlexW4311518932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.