Evidence map›Paper›PMID 36499641›Full record

ArticleInternational journal of molecular sciences2022

Longevity-Associated Variant of BPIFB4 Confers Neuroprotection in the STHdh Cell Model of Huntington Disease.

Monica Cattaneo, Anna Maciag, Maria Serena Milella, Elena Ciaglia, Antonino Bruno, Annibale Alessandro Puca

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. mEMBO reports · 2024
    Article
  4. Neurodegenerative Diseases: Molecular Mechanisms and Therapies.International journal of molecular sciences · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Monica CattaneoCardiovascular Department, IRCCS MultiMedica, 20138 Milan, Italy.
Anna MaciagCardiovascular Department, IRCCS MultiMedica, 20138 Milan, Italy.ORCID 0000-0001-6562-5640
Maria Serena MilellaCardiovascular Department, IRCCS MultiMedica, 20138 Milan, Italy.ORCID 0000-0001-5558-7601
Elena CiagliaDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Salerno, Italy.ORCID 0000-0002-8035-4583
Antonino BrunoLaboratory of Innate Immunity, Unit of Molecular Pathology, Biochemistry and Immunology, IRCCS MultiMedica, 20138 Milan, Italy.ORCID 0000-0002-4790-0861
Annibale Alessandro PucaCardiovascular Department, IRCCS MultiMedica, 20138 Milan, Italy.ORCID 0000-0002-0347-1460
MultiMedica · ITUniversity of Salerno · ITUniversity of Insubria · IT

Funding

Fondazione Cariplo ID 2019-1609Italian Association for Cancer Research AIRC-MFAG, ID 22818
6 · The paper itself

Abstract

Huntington's disease (HD) is caused by the production of mutant Huntingtin (mHTT), characterized by long polyglutamine repeats with toxic effects. There are currently no clinically validated therapeutic agents that slow or halt HD progression, resulting in a significant clinical unmet need. The striatum-derived STHdh cell line, generated from mHTT knock-in mouse embryos (STHdh

Indexed as

Huntington DiseaseAnimalsApoptosisCorpus StriatumDisease Models, AnimalGenetic VariationHuntingtin ProteinIntercellular Signaling Peptides and ProteinsMiceNeostriatumNeuroprotectionBpifb4 protein, mouseHuntingtin ProteinIntercellular Signaling Peptides and Proteinsapoptosis and heterochromatinDNA damageHuntington diseasemutant Huntingtinnucleolar stress

Identifiers

PMID36499641
PMCPMC9737551
OpenAlexW4310677092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.