Evidence map›Paper›PMID 36499618›Full record

ArticleInternational journal of molecular sciences2022

Synthesis, Biological Evaluation and Computational Studies of New Hydrazide Derivatives Containing 1,3,4-Oxadiazole as Antitubercular Agents.

Daniele Zampieri, Sara Fortuna, Maurizio Romano, Alessandro De Logu, Gianluigi Cabiddu, Adriana Sanna, Maria Grazia Mamolo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniele ZampieriDepartment of Chemistry and Pharmaceutical Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy.ORCID 0000-0002-1397-7334
Sara FortunaItalian Institute of Technology (IIT), Via E. Melen 83, 16152 Genova, Italy.ORCID 0000-0002-8059-6064
Maurizio RomanoDepartment of Life Sciences, University of Trieste, Via Valerio 28/1, 34127 Trieste, Italy.ORCID 0000-0002-4820-2897
Alessandro De LoguDepartment of Life and Environmental Sciences, Section of Microbiology, University of Cagliari, 09042 Monserrato, Italy.
Gianluigi CabidduDepartment of Life and Environmental Sciences, Section of Microbiology, University of Cagliari, 09042 Monserrato, Italy.
Adriana SannaDepartment of Public Health, Clinical and Molecular Medicine, University of Cagliari, 09042 Monserrato, Italy.
Maria Grazia MamoloDepartment of Chemistry and Pharmaceutical Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To extend our screening for novel antimycobacterial molecules, we have designed, synthesized, and biologically evaluated a library of 14 new hydrazide derivatives containing 1,3,4-oxadiazole core. A variety of mycobacterial strains, including some drug-resistant strains, were tested for antimycobacterial activity. Among the compounds tested, five showed high antimycobacterial activity (MIC values of 8 μg/mL) against

Indexed as

Mycobacterium tuberculosisNeuroblastomaAntitubercular AgentsFungiHumansHydrazinesMicrobial Sensitivity TestsMolecular Docking SimulationOxadiazolesStructure-Activity Relationship1,3,4-oxadiazoleAntitubercular AgentsHydrazinesOxadiazolesantimycobacterialhydrazideInhAMICoxadiazoletuberculosis

Identifiers

PMID36499618
PMCPMC9735621

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.