Evidence map›Paper›PMID 36499592›Full record

ArticleInternational journal of molecular sciences2022

Genetic and Structural Data on the SARS-CoV-2 Omicron BQ.1 Variant Reveal Its Low Potential for Epidemiological Expansion.

Fabio Scarpa, Daria Sanna, Domenico Benvenuto, Alessandra Borsetti, Ilenia Azzena, Marco Casu, Pier Luigi Fiori, Marta Giovanetti, Antonello Maruotti, Giancarlo Ceccarelli and 6 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. On the SARS-CoV-2 Variants.Infectious disease reports · 2024
    Article
  9. Article
  10. Article
  11. Integrative Genome-Based Survey of the SARS-CoV-2 Omicron XBB.1.16 Variant.International journal of molecular sciences · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Fabio ScarpaDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-3501-714X
Daria SannaDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-3058-4663
Domenico BenvenutoUnit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, 00128 Rome, Italy.ORCID 0000-0003-3833-2927
Alessandra BorsettiNational HIV/AIDS Research Center, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-5401-135X
Ilenia AzzenaDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Marco CasuDepartment of Veterinary Medicine, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-5042-4851
Pier Luigi FioriDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0001-6190-612X
Marta GiovanettiFlavivirus Laboratory, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0002-5849-7326
Antonello MaruottiDepartment GEPLI, Libera Università Ss Maria Assunta, 00193 Rome, Italy.ORCID 0000-0001-8377-9950
Giancarlo CeccarelliDepartment of Public Health and Infectious Diseases, University Hospital Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-5921-3180
Arnaldo CarusoDepartment of Molecular and Translational Medicine, Section of Microbiology, University of Brescia, 25123 Brescia, Italy.
Francesca CaccuriDepartment of Molecular and Translational Medicine, Section of Microbiology, University of Brescia, 25123 Brescia, Italy.
Roberto CaudaUOC Malattie Infettive, Infectious Disease Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
Antonio CassoneCenter of Genomic, Genetic and Biology, 53100 Siena, Italy.
Stefano PascarellaDepartment of Biochemical Sciences "A Rossi Fanelli", Sapienza Università di Roma, 00161 Rome, Italy.ORCID 0000-0002-6822-4022
Massimo CiccozziUnit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, 00128 Rome, Italy.ORCID 0000-0003-3866-9239

Funding

Marta Giovanetti is funded by PON "Ricerca e Innovazione" 2014-2020 NAStefano Pascarella is in part supported by the Sapienza RP12117A7670A1E8This research was funded from by FONDAZIONE DI SARDEGNA bando 2022-2023 for the Dipartimento di Scienze Biomediche - UNISS (to Daria Sanna and Fabio Scarpa) NA
6 · The paper itself

Abstract

The BQ.1 SARS-CoV-2 variant, also known as Cerberus, is one of the most recent Omicron descendant lineages. Compared to its direct progenitor BA.5, BQ.1 has some additional spike mutations in some key antigenic sites, which confer further immune escape ability over other circulating lineages. In such a context, here, we perform a genome-based survey aimed at obtaining a complete-as-possible nuance of this rapidly evolving Omicron subvariant. Genetic data suggest that BQ.1 represents an evolutionary blind background, lacking the rapid diversification that is typical of a dangerous lineage. Indeed, the evolutionary rate of BQ.1 is very similar to that of BA.5 (7.6 × 10

Indexed as

COVID-19Bayes TheoremBiological EvolutionHumansSARS-CoV-2BQ.1coronavirusepidemiologypandemicsSARS coronavirusvirus classification

Identifiers

PMID36499592
PMCPMC9739521

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.