Evidence map›Paper›PMID 36499518›Full record

ArticleInternational journal of molecular sciences2022

Amorphous Solid Dispersion of Hesperidin with Polymer Excipients for Enhanced Apparent Solubility as a More Effective Approach to the Treatment of Civilization Diseases.

Natalia Rosiak, Kamil Wdowiak, Ewa Tykarska, Judyta Cielecka-Piontek

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

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  14. Formulation, characterization and and evaluation of aloe-emodin-loaded solid dispersions for dissolution enhancement.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024
    Article
  15. The Study of Amorphous Kaempferol Dispersions Involving FT-IR Spectroscopy.International journal of molecular sciences · 2023
    Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Natalia RosiakDepartment of Pharmacognosy, Faculty of Pharmacy, Poznan University of Medical Sciences, 3 Rokietnicka St., 60-806 Poznan, Poland.ORCID 0000-0003-4722-6413
Kamil WdowiakDepartment of Pharmacognosy, Faculty of Pharmacy, Poznan University of Medical Sciences, 3 Rokietnicka St., 60-806 Poznan, Poland.
Ewa TykarskaDepartment of Chemical Technology of Drugs, Poznan University of Medical Sciences, 6 Grunwaldzka St., 60-780 Poznan, Poland.ORCID 0000-0001-9393-3536
Judyta Cielecka-PiontekDepartment of Pharmacognosy, Faculty of Pharmacy, Poznan University of Medical Sciences, 3 Rokietnicka St., 60-806 Poznan, Poland.ORCID 0000-0003-0891-5419
Poznan University of Medical Sciences · PL

Funding

National Science Center UMO-2020/37/B/NZ7/03975
6 · The paper itself

Abstract

The present study reports amorphous solid dispersions (ASDs) of hesperidin (Hes) prepared by ball milling to improve its solubility and apparent solubility over the unmodified compound. The carriers were Soluplus

Indexed as

ExcipientsPolymersDrug StabilityHypromellose DerivativesPhosphatesPolyethylene GlycolsPolyvinylsSolubilitySpectroscopy, Fourier Transform InfraredExcipientsHypromellose DerivativesPhosphatesPolyethylene GlycolsPolymerspolyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymerPolyvinylsamorphous solid dispersionapparent solubilityDFT calculationglass transitionGordon–Taylor equationhesperidin

Identifiers

PMID36499518
PMCPMC9740072
OpenAlexW4310675987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.