Evidence map›Paper›PMID 36499507›Full record

ArticleInternational journal of molecular sciences2022

Inhibitory Effects of Nobiletin on Voltage-Gated Na

Youwei Gu, Jieru Wang, Mengting Li, Fei Zhong, Jie Xiang, Zhengxin Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Youwei GuDepartment of Pharmacology, School of Medicine, Yangzhou University, Yangzhou 225009, China.
Jieru WangDepartment of Pharmacology, School of Medicine, Yangzhou University, Yangzhou 225009, China.
Mengting LiDepartment of Pharmacology, School of Medicine, Yangzhou University, Yangzhou 225009, China.
Fei ZhongDepartment of Pharmacology, School of Medicine, Yangzhou University, Yangzhou 225009, China.
Jie XiangDepartment of Pharmacology, School of Medicine, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-3107-9888
Zhengxin XuDepartment of Pharmacology, School of Medicine, Yangzhou University, Yangzhou 225009, China.
Yangzhou University · CNIntegrated Chinese Medicine (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nobiletin (NOB) has attracted much attention owing to its outstanding bioactivities. This study aimed to investigate its anti-arrhythmic effect through electrophysiological and molecular docking studies. We assessed the anti-arrhythmic effects of NOB using aconitine-induced ventricular arrhythmia in a rat model and the electrophysiological effects of NOB on rat cardiomyocytes utilizing whole-cell patch-clamp techniques. Moreover, we investigated the binding characters of NOB with rNav1.5, rNav1.5/QQQ, and hNa

Indexed as

Anti-Arrhythmia AgentsMyocytes, CardiacAconitineAnimalsArrhythmias, CardiacMolecular Docking SimulationPatch-Clamp TechniquesRatsSodiumSodium ChannelsAconitineAnti-Arrhythmia AgentsSodiumSodium Channelsaconitineamiodaronearrhythmiamolecular docking simulationNaV1.5 channelnobiletinventricular myocytes

Identifiers

PMID36499507
PMCPMC9736168
OpenAlexW4311514634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.